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Active Recombinant Human Erythropoietin

Cat.No. : EPO-269H
Product Overview : Human EPO (P01588, 1 aa-193 aa) full-length recombinant protein expressed in Escherichia coli.
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Cat. No. : EPO-269H
Description : Erythropoietin, or its alternatives erythropoetin or erithropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Also called hematopoietin or hemopoietin, it is produced by the peritubular capillary endothelial cells in the kidney and liver, it is the hormone that regulates red blood cell production. It also has other known biological functions. For example, erythropoietin plays an important role in the brain"s response to neuronal injury. EPO is also involved in the wound healing process. When exogenous EPO is used as a performance-enhancing drug, it is classified as an erythropoiesis-stimulating agent (ESA). Exogenous EPO can often be detected in blood, due to slight difference from the endogenous protein, for example in features of posttranslational modification.
Sequence : MGVHECPAWL WLLLSLLSLP LGLPVLGAPP RLICDSRVLE RYLLEAKEAE NITTGCAEHC SLNENITVPD TKVNFYAWKR MEVGQQAVEV WQGLALLSEA VLRGQALLVN SSQPWEPLQL HVDKAVSGLR SLTTLLRALG AQKEAISPPD AASAAPLRTI TADTFRKLFR VYSNFLRGKL KLYTGEACRT GDR
Theoretical MW (kDa) : 20
Form : Lyophilized
Preparation Method : Escherichia coli expression system
Purification : Ion exchange column and HPLC reverse phase column.
Purity : > 98% by SDS-PAGE and HPLC
Endotoxin Level : < 0.1 ng/ug (1 EU/ug)
Activity : Activity was determined by the dose-dependent proliferation assay using a factor-dependent human erythroleukemic cell line TF-1 and was found to be 3.8 x 10⁵ IU/mg.
Application : SDS-PAGE
Storage Buffer : Lyophilized from PBS, pH 7.
Storage : Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
Unitprot ID : P01588
Gene Name : EPO erythropoietin [ Homo sapiens ]
Official Symbol : EPO
Synonyms : EP; MGC138142; Epoetin; Erythropoietin Precursor; EPO; erythropoietin; OTTHUMP00000201234; MVCD2
Gene ID : 2056
mRNA Refseq : NM_000799
Protein Refseq : NP_000790
MIM : 133170
Chromosome Location : 7q22
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Paxillin-independent events mediated by a4b1 and a4b7; Signaling events mediated by Stem cell factor receptor (c-Kit); HIF-2-alpha transcription factor network; HIF-1-alpha transcription factor network; EPO Receptor Signaling; EPO signaling pathway
Function : erythropoietin receptor binding IEA ;hormone activity IEA ;protein binding; eukaryotic cell surface binding; protein kinase activator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship between EPO protein and cardiovascular disease? 08/05/2019

EPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.

How does EPO protein regulate erythropoiesis? 07/12/2019

By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.

How about the clinical use of EPO protein? 06/12/2019

EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.

What are the implications of EPO protein research for the future of treating anemia? 05/14/2019

The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.

How is EPO protein treated for anemia? 05/02/2019

This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.

What is the role of EPO protein in kidney disease? 04/04/2019

In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.

Customer Reviews (3)

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Reviews
12/28/2021

    Stability is truly remarkable, can maintain its activity even under extreme conditions.

    08/31/2021

      Can catalyze reactions even under extreme conditions.

      02/03/2019

        This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

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