"FAS" Related Products

Recombinant Human Fas (TNF Receptor Superfamily, Member 6)

Cat. No.: FAS-4270H
Product Overview: Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids. The FAS antigen is purified by proprietary chromatographic techniques.
Description: FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.
Source: Human
Host: Escherichia Coli.
Form: 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME.
Purity: Greater than 95% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Physical Appearance: Sterile liquid formulation.
Storage: CD95 although stable at 10°C for 5 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ]
Official Symbol: FAS
Synonyms: FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen
Gene ID: 355
mRNA Refseq: NM_000043
Protein Refseq: NP_000034
MIM: 134637
UniProt ID: P25445
Chromosome Location: 10q24.1
Pathway: Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis
Function: identical protein binding; kinase binding; transmembrane receptor activity

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