"FGF2" Related Products

Recombinant Human Fibroblast Growth Factor 2 (basic)

Cat. No.: FGF2-567H
Product Overview: A single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of angiogenesis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor. Recombinant Human FGF-b (FGF-2) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16,539 Daltons.
Description: Basic fibroblast growth factor, also known as bFGF, FGF2 or FGF-μ, is a member of the fibroblast growth factorfamily.
Species: Human
Source: E.coli
Form: The protein was lyophilized from a 10 mM NaP, pH 8.0.
Purity: Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity: Recombinant Human Fibroblast Growth Factor-beta is fully biologically active when compared to standards. The ED50, calculated by the dose-dependant proliferation of mouse BALB/c 3T3 cells is 0.12 ng/ml.
Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility: Centrifuge vial before opening. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by: UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level: Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence: MPALPEDGGS GAFPPGHFKD PKRLYCKNGG FFLRIHPDGR VDGVREKSDP HIKLQLQAEE RGVVSIKGVC ANRYLAMKED GRLLASKCVT DECFFFERLE SNNYNTYRSR KYTSWYVALK RTGQYKLGSK TGPGQKAILF LPMSAKS
Storage: Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name: FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens ]
Official Symbol: FGF2
Synonyms: FGF2; fibroblast growth factor 2 (basic); BFGF; FGFB; HBGF-2; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor Bfgf; Basic fibroblast growth factor
Gene ID: 2247
mRNA Refseq: NM_002006
Protein Refseq: NP_001997
MIM: 134920
UniProt ID: P09038
Chromosome Location: 4q26
Pathway: MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; aling by FGFR; SHC-mediated cascade; Syndecan-4-mediated signaling events; PI3K Cascade; Insulin receptor signalling cascade; Glypican 1 network; FGFR3c ligand binding and activation
Function: growth factor activity; heparin binding; protein binding; voltage-gated calcium channel activity; ligand-dependent nuclear receptor transcription coactivator activity; protein tyrosine kinase activity

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