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Recombinant Human Grancalcin, EF-hand Calcium Binding Protein, His-tagged

Cat.No. : GCA-4382H
Product Overview : GCA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217.a.) and having a molecular mass of 26.1kDa. GCA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
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Cat. No. : GCA-4382H
Description : GCA is calcium-binding protein which is particularly abundant in human neutrophils. GCA is a member of the penta EF-hand (PEF) subfamily of EF-hand proteins, who also comprises calpain, sorcin, peflin, and ALG-2. GCA undergoes essential conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, that direct the protein to hydrophobic surfaces. GCA cooperates with L-plastin, a protein known to have actin bundling activity, which suggests that GCA has a part in the regulation of neutrophils adhesion.
Source : Human
Host : Escherichia Coli.
Form : The GCA protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 20% glycerol.
Purity : Greater than 95% as determined by SDS-PAGE.
Physical Appearance : Sterile Filtered clear solution.
Amino acid sequence : MGSSHHHHHH SSGLVPRGSH MAYPGYGGGF GNFSIQVPGM QMGQPVPETG PAILLDGYSG PAYSDTYSSA GDSVYTYFSA VAGQDGEVDA EELQRCLTQS GINGTYSPFS LETCRIMIAM LDRDHTGKMG FNAFKELWAA LNAWKENFMT VDQDGSGTVE HHELRQAIGL MGYRLSPQTL TTIVKRYSKN GRIFFDDYVA CCVKLRALTD FFRKRDHLQQ GSANFIYDDF LQGTMAI
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Pathways : Insulin signaling pathway; mTOR signaling pathway
Gene Name : GCA grancalcin, EF-hand calcium binding protein [ Homo sapiens ]
Official Symbol : GCA
Synonyms : GCA; grancalcin, EF-hand calcium binding protein; GCL; grancalcin; OTTHUMP00000204639; OTTHUMP00000204640; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein
Gene ID : 25801
mRNA Refseq : NM_012198
Protein Refseq : NP_036330
MIM : 607030
UniProt ID : P28676
Chromosome Location : 2q37.1
Function : calcium ion binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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08/31/2020

    In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

    06/26/2019

      Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the GCA protein in my studies.

      09/12/2018

        The GCA protein comes highly recommended for its outstanding performance in various experimental applications.

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