"GMDS" Related Products

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Recombinant Human GDP-Mannose 4,6-Dehydratase, His-tagged

Cat. No.: GMDS-1282H
Product Overview: Recombinant human GMDS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Description: GMDS, also known as SDR3E1, belongs to the GDP-mannose 4,6-dehydratase family. This protein utilizes NADP as a cofactor to catalyze the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose. Mutations in the gene encoding GMDS are involved in resistance to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol 0.1M NaCl,1mM DTT, 0.1mM PMSF
Molecular Weight: 44.1 kDa (392aa), confirmed by MALDI-TOF
Purity: > 95% by SDS - PAGE
Concentration: 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA FDELVREMVH ADVELMRTNP NA
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism; Metabolic pathways
Gene Name: GMDS GDP-mannose 4,6-dehydratase [ Homo sapiens ]
Official Symbol: GMDS
Synonyms: GMDS; GDP-mannose 4,6-dehydratase; GMD; SDR3E1; OTTHUMP00000017756; OTTHUMP00000232770; GDP-D-mannose dehydratase; short chain dehydrogenase/reductase family 3E, member 1; EC 4.2.1.47
Gene ID: 2762
mRNA Refseq: NM_001500
Protein Refseq: NP_001491
MIM: 602884
UniProt ID: O60547
Chromosome Location: 6p25
Function: GDP-mannose 4,6-dehydratase activity; binding; coenzyme binding; lyase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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