Recombinant Human Heme Oxygenase (Decycling) 2

• Cat.No.: HMOX2-1343H
• Product Overview: HMOX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 264 amino acids (1-264 a.a.) and having a molecular mass of 30.5 kDa. HMOX2 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: HMOX2-1343H
• Description: HMOX2 cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently transferred to bilirubin by biliverdin reductase. Under physiological conditions, the activity of HMOX2 is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. HMOX2 participates in the production of carbon monoxide in the brain where it operates as a neurotransmitter. HMOX2 is an essential enzyme in heme catabolism and is involved in cellular response to oxidative stress.
• Source: Human
• Host: Escherichia Coli.
• Form: HMOX2 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Physical Appearance: Sterile filtered colorless solution.
• Amino acid sequence: SAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRK.
• Storage: HMOX2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

Gene Information

• Gene Name: HMOX2 heme oxygenase (decycling) 2 [ Homo sapiens ]
• Official Symbol: HMOX2
• Synonyms: HMOX2; heme oxygenase (decycling) 2; HO-2; EC 1.14.99.3; HO2; heme oxygenase (decyclizing) 2; Heme oxygenase 2
• Gene ID: 3163
• mRNA Refseq: NM_001127204
• Protein Refseq: NP_001120676
• MIM: 141251
• UniProt ID: P30519
• Chromosome Location: 16p13.3
• Pathway: Porphyrin and chlorophyll metabolism
• Function: electron carrier activity; heme oxygenase (decyclizing) activity; iron ion binding; metal ion binding; oxidoreductase activity; protein binding