"Il17a" Related Products

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Recombinant Rat Interleukin-17A

Cat. No.: Il17a-489R
Product Overview: Recombinant rat IL-17A produced in E.coli is a non-glycosylated disulfide-joined homodimer having a molecular mass of 30.0 kDa.
Description: Rat IL-17A (IL-17), also known as CTLA-8, is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Rat IL-17A protein is a homodimer consisting of two 134 amino acids peptides. IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most strikingly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. There is 58% identity between the amino acid sequence of human and rat IL-17A.
Species: Rat
Source: E.coli
Form: Lyophilized with no additives.
Purity: Purity Greater than 97% as determined by: Reducing and non-reducing SDS-PAGE.
Bio-activity: Rat IL-17A is fully biologically active when compared to standards via dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibrolasts. The ED50 for recombinant rat IL-17A in this assay was 30ng/ml.
Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg"s/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 97% as determined by: Reducing and non-reducing SDS-PAGE.
Protein Content determined by: UV spectroscopy at 280 nm. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level: Endotoxin level is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS
Storage: Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name: Il17a interleukin 17A [ Rattus norvegicus ]
Official Symbol: Il17a
Synonyms: Il17a; interleukin 17A; Il17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Gene ID: 301289
mRNA Refseq: NM_001106897
Protein Refseq: NP_001100367
UniProt ID: Q61453
Function: cytokine activity

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