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Active Recombinant Human IL21 Protein

Cat.No. : IL21-501H
Product Overview : Recombinant Human IL21 was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain ( centigrade) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Source : E. coli
Species : Human
Form : Lyophilized from PBS, pH 7.4.
Bio-activity : Measured by its ability to proliferate activated B cells.
Molecular Mass : IL21 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a total molecular mass of 15.4kDa.
AA Sequence : MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS.
Purity : Greater than 97.0% as determined by SDS-PAGE.
Storage : Lyophilized Interleukin-21 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution IL21 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized Interleukin -21 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Publication :
Cytokine and reactivity profiles in SLE patients following anti-CD19 CART therapy (2023)
Gene Name : IL21 interleukin 21 [ Homo sapiens ]
Official Symbol : IL21
Synonyms : IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21;
Gene ID : 59067
mRNA Refseq : NM_001207006
Protein Refseq : NP_001193935
MIM : 605384
UniProt ID : Q9HBE4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which types of cancer has IL21 protein shown promising results? 02/17/2023

IL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.

Are there any side effects associated with IL21 therapy? 11/12/2021

Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.

Can IL21 be used as a standalone treatment for cancer? 09/17/2021

IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.

Are there any ongoing clinical trials exploring the use of IL21 in autoimmune conditions? 03/04/2020

Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.

How does IL21 influence the development of memory T cells? 10/29/2018

IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.

Customer Reviews (3)

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Reviews
08/19/2022

    With the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.

    01/30/2022

      I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes

      04/23/2019

        Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.

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