Recombinant Rat Interleukin-4

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Recombinant Rat Interleukin-4

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Cat. No. : IL4-411R
Product Overview : Interleukin-4 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 14105 Dalton. The IL-4 is purified by proprietary chromatographic techniques.
Description : IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source : Rat
Host : Escherichia Coli.
Form : Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Purity : Greater than 98.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Bio-activity : The ED50 as determined by the dose-dependant prolifiration of Con A activated rat spleen cells is < 1.5 ng/ml, corresponding to a Specific Activity of 660,000 IU/mg.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized Interleukin 4 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Met-His-Gly-Cys-Asn.
Storage : Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Crystalstructure of human IL-4 (2INT) :

Gene Name : Il4 interleukin 4 [ Rattus norvegicus ]
Official Symbol : IL4
Synonyms : interleukin-4; IL-4; BSF-1; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IGG differentiation factor
Gene ID : 287287
mRNA Refseq : NM_201270
Protein Refseq : NP_958427
UniProt ID : P20096
Chromosome Location : 10q22
Pathway : Allograft rejection; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; Intestinal immune network for IgA production; Jak-STAT signaling pathway
Function : cytokine activity; growth factor activity; interleukin-4 receptor binding

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