Recombinant Rat Interleukin-4
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| Cat. No. : | IL4-411R |
| Product Overview : | Interleukin-4 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 14105 Dalton. The IL-4 is purified by proprietary chromatographic techniques. |
| Description : | IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Source : | Rat |
| Host : | Escherichia Coli. |
| Form : | Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
| Purity : | Greater than 98.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Bio-activity : | The ED50 as determined by the dose-dependant prolifiration of Con A activated rat spleen cells is < 1.5 ng/ml, corresponding to a Specific Activity of 660,000 IU/mg. |
| Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Solubility : | It is recommended to reconstitute the lyophilized Interleukin 4 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Amino acid sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Met-His-Gly-Cys-Asn. |
| Storage : | Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Crystalstructure of human IL-4 (2INT) : |
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| Gene Name : | Il4 interleukin 4 [ Rattus norvegicus ] |
| Official Symbol : | IL4 |
| Synonyms : | interleukin-4; IL-4; BSF-1; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IGG differentiation factor |
| Gene ID : | 287287 |
| mRNA Refseq : | NM_201270 |
| Protein Refseq : | NP_958427 |
| UniProt ID : | P20096 |
| Chromosome Location : | 10q22 |
| Pathway : | Allograft rejection; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; Intestinal immune network for IgA production; Jak-STAT signaling pathway |
| Function : | cytokine activity; growth factor activity; interleukin-4 receptor binding |
◆ Recombinant Protein
| IL4-4323O | Recombinant Ovine IL4 Protein | +Inquiry |
| IL4-139H | Recombinant Human IL4 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
| Il4-2098M | Recombinant Mouse Il4 Protein | +Inquiry |
| Il4-109M | Recombinant Mouse Il4 Protein | +Inquiry |
| IL4-001H | Recombinant Human IL4 Protein, His-tagged | +Inquiry |
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◆ Lysates
| IL4-001MCL | Recombinant Mouse IL4 cell lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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