Recombinant Human IL6 (29-212aa)

Cat. No.: IL6-031E
Product Overview: Recombinant Human IL6 (Pro29 ­ Met212) was expressed in E. coli and produced using non­animal reagent in an animal­free laboratory.
Description: Interleukin 6 (IL­6) is a pleiotropic α­helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL­6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa ­ 28 kDa phosphorylated and variably glycosylated molecule. IL­6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL­6 R) and a signal transducing subunit (gp130). IL ­6 binds to IL­6 R, triggering IL ­6 R association with gp130 and gp130 dimerization.
Source: E. coli
N­terminal Sequence Analysi: Pro29
Molecular Mass: 20.3 kDa
Activity: Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. The ED50 for this effect is typically 0.2 ­ 0.8 ng/mL.
Endotoxin Leve: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: Use a manual defrost freezer and avoid repeated freeze­thaw cycles. 1. 12 months from date of receipt, ­20 to ­70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Unitprot ID: P05231
Gene Name: IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]
Official Symbol: IL6
Synonyms: IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B cell stimulatory factor-2; B-cell stimulatory factor 2; B-cell differentiation factor
Gene ID: 3569
mRNA Refseq: NM_000600
Protein Refseq: NP_000591
MIM: 147620
Chromosome Location: 7p21
Pathway: Androgen Receptor Signaling Pathway; Cytosolic DNA-sensing pathway; Hypertrophic cardiomyopathy (HCM); IL-6 Signaling Pathway; Jak-STAT signaling pathway; NOD-like receptor signaling pathway; SIDS Susceptibility Pathways; Selenium Pathway; Toll-like receptor signaling pathway
Function: cytokine activity; growth factor activity; interleukin-6 receptor binding; interleukin-6 receptor binding

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