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| Cat. No.: | IL6-031E |
| Product Overview: | Recombinant Human IL6 (Pro29 Met212) was expressed in E. coli and produced using nonanimal reagent in an animalfree laboratory. |
| Description: | Interleukin 6 (IL6) is a pleiotropic αhelical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa 28 kDa phosphorylated and variably glycosylated molecule. IL6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL6 R) and a signal transducing subunit (gp130). IL 6 binds to IL6 R, triggering IL 6 R association with gp130 and gp130 dimerization. |
| Source: | E. coli |
| Nterminal Sequence Analysi: | Pro29 |
| Molecular Mass: | 20.3 kDa |
| Activity: | Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. The ED50 for this effect is typically 0.2 0.8 ng/mL. |
| Endotoxin Leve: | <1.0 EU per 1 μg of the protein by the LAL method. |
| Purity: | >97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details. |
| Reconstitution: | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping: | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, 20 to 70 °C under sterile conditions after reconstitution. |
| Unitprot ID: | P05231 |
| Gene Name: | IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ] |
| Official Symbol: | IL6 |
| Synonyms: | IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B cell stimulatory factor-2; B-cell stimulatory factor 2; B-cell differentiation factor |
| Gene ID: | 3569 |
| mRNA Refseq: | NM_000600 |
| Protein Refseq: | NP_000591 |
| MIM: | 147620 |
| Chromosome Location: | 7p21 |
| Pathway: | Androgen Receptor Signaling Pathway; Cytosolic DNA-sensing pathway; Hypertrophic cardiomyopathy (HCM); IL-6 Signaling Pathway; Jak-STAT signaling pathway; NOD-like receptor signaling pathway; SIDS Susceptibility Pathways; Selenium Pathway; Toll-like receptor signaling pathway |
| Function: | cytokine activity; growth factor activity; interleukin-6 receptor binding; interleukin-6 receptor binding |
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