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Recombinant Human IMP (Inosine 5'-Monophosphate) Dehydrogenase 2, His-tagged

Cat.No. : IMPDH2-1274H
Product Overview : Recombinant human IMPDH2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Cat. No. : IMPDH2-1274H
Description : IMPDH2 belongs to the IMPDH/GMPR family. It catalyzes the NAD-dependent oxidation of inosine-5"-monophosphate into xanthine-5"-monophosphate, which is then converted into guanosine-5"-monophosphate. IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. Also IMPDH1 and IMPDH2 are targets for the important immunosuppressive drug, mycophenolic acid (MPA).
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl
Molecular Weight : 58.0kDa (534aa)
Purity : > 90% by SDS - PAGE
Concentration : 0.5mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Pathways : Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Purine ribonucleoside monophosphate biosynthesis
Gene Name : IMPDH2 IMP (inosine 5"-monophosphate) dehydrogenase 2 [ Homo sapiens ]
Official Symbol : IMPDH2
Synonyms : IMPDH2; IMPDH 2; IMPD2; IMPD 2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPDH-II; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMP dehydrogenase 2; inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2; EC 1.1.1.205; OTTHUMP00000210556
Gene ID : 3615
mRNA Refseq : NM_000884
Protein Refseq : NP_000875
MIM : 146691
UniProt ID : P12268
Chromosome Location : 3p21.2
Function : IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which signaling pathways or molecules does IMPDH2 interact with? 12/25/2019

The purine metabolism related signal pathways and molecular interactions, such as AMPK pathway, GTP enzyme amp-activated protein and purine nucleotide made, etc.

How about the regulatory factors IMPDH2? 12/10/2019

It can control by a variety of factors, such as ATP, GTP, AMPK and made mTOR signaling pathways, such as active state, and other factors relating to the cell cycle and cell differentiation.

What role does IMPDH2 play in tumor development? 11/12/2019

It is highly expressed in tumor cells. It is involved in the regulation of purine metabolism and nucleotide synthesis, and may play an important role in tumor cell proliferation and survival.

What biological processes or metabolic pathways does IMPDH2 play a role in? 09/29/2019

This protein is involved in purine metabolic pathway and is one of the key enzymes for purine nucleotide synthesis. It plays an important role in biological processes such as embryonic development and immune regulation.

How does IMPDH2 play a role in immune regulation? 07/30/2019

It is involved in the regulation of purine metabolism and T cell activation in immune regulation, and may play an important role in the regulation of immune cell function and inflammatory response.

How to prepare the recombinant IMPDH2 protein and what are its applications? 07/15/2019

Can be induced by cloning and expression of of IMPDH2, applied in drug discovery and gene function research and other fields.

Customer Reviews (3)

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Reviews
10/22/2021

    I'm very satisfied. The quality is good and the price is affordable.

    10/15/2021

      Good activity, can maintain long-term activity.

      06/15/2019

        Very easy to use and highly recommended.

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