Active Recombinant Human KITLG (26-189aa), Met tagged
Cat.No. : | KITLG-036E |
Product Overview : | Recombinant Human KITLG (Glu26 Ala189, with an Nterminal Met) was expressed in E. coli and produced using nonanimal reagent in an animalfree laboratory. |
- Specification
- Gene Information
- Related Products
Cat. No. : | KITLG-036E |
Description : | Stem cell factor (SCF), also known as ckit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels. |
Source : | E. coli |
Nterminal Sequence Analysi : | Met |
Molecular Mass : | 18.6 kDa |
Activity : | Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The ED50 for this effect is typically 1 5 ng/mL. |
Endotoxin Leve : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Formulation : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. See Certificate of Analysis for details. |
Reconstitution : | Reconstitute at 0.2 mg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Storage : | Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, 20 to 70 °C under sterile conditions after reconstitution. |
Unitprot ID : | P21583 |
Gene Name : | KITLG KIT ligand [ Homo sapiens ] |
Official Symbol : | KITLG |
Synonyms : | KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; DKFZp686F2250; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2 |
Gene ID : | 4254 |
mRNA Refseq : | NM_003994 |
Protein Refseq : | NP_003985 |
MIM : | 184745 |
Chromosome Location : | 12q22 |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Kit Receptor Signaling Pathway; Melanogenesis; Pathways in cancer |
Function : | cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding |
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◆ Lysates | ||
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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