Recombinant Human KITLG, His tagged
Cat.No. : | KITLG-558H |
Product Overview : | Recombinant Human KITLG (P21583-1) extracellular domain amino acid (Met 1-Ala 189), fused with a polyhistidine tag at the C-terminus, was produced in Baculovirus-Insect cells. |
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Source : | Baculovirus-Insect Cells |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0 |
Molecular Mass : | The secreted recombinant human SCF (aa 1-189) consists of 175 amino acids and predicts a molecular mass of 19.9 kDa. The apparent molecular mass of rh SCF is approximately 22 kDa in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | KITLG KIT ligand [ Homo sapiens ] |
Official Symbol : | KITLG |
Gene ID : | 4254 |
mRNA Refseq : | NM_000899 |
Protein Refseq : | NP_000890 |
MIM : | 184745 |
UniProt ID : | P21583 |
Products Types
◆ Recombinant Protein | ||
KITLG-829M | Recombinant Mouse KITLG Protein (Met1-Ala189), His-tagged, Biotinylated | +Inquiry |
KITLG-2737D | Recombinant Dog KITLG Protein, His-tagged | +Inquiry |
KITLG-057K | Active Recombinant Human KITLG Protein (165 aa) | +Inquiry |
KITLG-4355S | Recombinant Swine KITLG Protein | +Inquiry |
KITLG-4356R | Recombinant Rabbit KITLG Protein | +Inquiry |
◆ Lysates | ||
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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