Recombinant Proliferating Cell Nuclear Antigen, GST-tagged
Cat.No. : | PCNA-4488H |
Product Overview : | PCNA full length Human Recombinant protein produced in E.Coli is a single, non-glycosylated polypeptide chain having a molecular mass of 62kDa which includes GST-tag fusion protein. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PCNA-4488H |
Description : | PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | The PCNA solution contains 50mM Tris-Acetate pH-7.5 & 1mM EDTA & 20% glycerol. |
Physical Appearance : | Sterile Filtered colorless solution. |
Storage : | PCNA although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Pathways : | Base excision repair; Cell cycle; DNA replication; Mismatch repair; Nucleotide excision repair; Cell Cycle, Mitotic; DNA Repair; DNA Replication; Telomere Maintenance |
Gene Name : | PCNA proliferating cell nuclear antigen [ Homo sapiens ] |
Official Symbol : | PCNA |
Synonyms : | MGC8367; PCNA; Proliferating cell nuclear antigen; Cyclin; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein |
Gene ID : | 5111 |
mRNA Refseq : | NM_002592 |
Protein Refseq : | NP_002583 |
MIM : | 176740 |
UniProt ID : | P12004 |
Chromosome Location : | 20pter-p12 |
Function : | DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
PCNA-500HCL | Recombinant Human PCNA cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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