Recombinant Human Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3, His-tagged
Cat.No. : | PSMA3-1287H |
Product Overview : | Recombinant human PSMA3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PSMA3-1287H |
Description : | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.15M NaCl. |
Molecular Weight : | 30.6 kDa (275aa), confirmed by MALDI-TOF |
Purity : | > 95 % by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV HAYTLYSAVR PFGCSFMLGS YSVNDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL QMKEMTCRDI VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TNGRHEIVPK DIREEAEKYA KESLKEEDES DDDNM |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; Cell Cycle; Degradation of beta-catenin by the destruction complex; G1/S DNA Damage Checkpoints |
Gene Name : | PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 [ Homo sapiens ] |
Official Symbol : | PSMA3 |
Synonyms : | PSMA3; proteasome (prosome, macropain) subunit, alpha type, 3; HC8; PSC3; MGC12306; MGC32631; proteasome subunit alpha type-3; OTTHUMP00000179019; macropain subunit C8; proteasome subunit C8; proteasome component C8; multicatalytic endopeptidase complex subunit C8; Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; EC 3.4.25.1 |
Gene ID : | 5684 |
mRNA Refseq : | NM_002788 |
Protein Refseq : | NP_002779 |
MIM : | 176843 |
UniProt ID : | P25788 |
Chromosome Location : | 14q23 |
Function : | peptidase activity; protein binding; threonine-type endopeptidase activity |
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◆ Native Protein | ||
PSMA3-419S | Active Native S. aureus PSM-alpha 3 protein | +Inquiry |
◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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