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Recombinant Human Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta), His-tagged

Cat.No. : PSME2-1288H
Product Overview : Recombinant human PSME2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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  • Gene Information
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Cat. No. : PSME2-1288H
Description : PSME2, also known as proteasome (prosome, macropain) activator subunit 2, is an IFN-gamma inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. Downregulation of PSME2 results in abnormal proteasome activation and has been implicated in the development of intimal hyperplasia (IH) in animal models.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT, 0.1mM PMSF
Molecular Weight : 29.5 kDa (259aa), confirmed by MALDI-TOF
Purity : > 95% by SDS - PAGE
Concentration : 1.0 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : APC/C:Cdc20 mediated degradation of mitotic proteins; Antigen processing: Ubiquitination & Proteasome degradation; Apoptosis; Cell Cycle; DNA Replication Pre-Initiation
Gene Name : PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [ Homo sapiens ]
Official Symbol : PSME2
Synonyms : PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); PA28B; REGbeta; PA28beta; proteasome activator complex subunit 2; REG-beta; OTTHUMP00000027977; MCP activator, 31-kD subunit; proteasome activator 28-beta; 11S regulator complex beta subunit; 11S regulator complex subunit beta; cell migration-inducing protein 22; proteasome activator 28 subunit beta; proteasome activator hPA28 subunit beta; activator of multicatalytic protease subunit 2; Proteasome activator complex subunit 2; 11S regulator complex subunit beta; Proteasome activator 28 subunit beta; Activator of multicatalytic protease subunit 2; PA28b
Gene ID : 5721
mRNA Refseq : NM_002818
Protein Refseq : NP_002809
MIM : 602161
UniProt ID : Q9UL46
Chromosome Location : 14q11.2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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