Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, C

• Cat.No.: PTPRC-4265H
• Product Overview: CD45 Human Recombinant (aa 1102-1150) expressed in E.coli, shows a 33 kDa band on SDS-PAGE (Including GST). The CD45 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: PTPRC-4265H
• Description: CD45 leukocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals.
• Source: Human
• Host: Escherichia Coli.
• Form: CD45 at 100µg/1ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Physical Appearance: Sterile Filtered clear solution.
• Storage: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: PTPRC protein tyrosine phosphatase, receptor type, C [ Homo sapiens ]
• Official Symbol: PTPRC
• Synonyms: PTPRC; protein tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45; T200; CD45R; GP180; CD45 antigen; glycoprotein; T200 glycoprotein; leukocyte-common antigen; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; Leukocyte common antigen; L-CA; EC 3.1.3.48; protein tyrosine phosphatase, receptor type, c polypeptide
• Gene ID: 5788
• mRNA Refseq: NM_002838
• Protein Refseq: NP_002829
• MIM: 151460
• UniProt ID: P08575
• Chromosome Location: 1q31-q32
• Pathway: Cell adhesion molecules (CAMs); Fc gamma R-mediated phagocytosis; Primary immunodeficiency; T cell receptor signaling pathway; Axon guidance; Signaling in Immune system
• Function: heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity