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Recombinant Mouse Reticulon 4 Receptor, His-tagged

Cat.No. : Rtn4r-4009M
Product Overview : A DNA sequence encoding the the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Cat. No. : Rtn4r-4009M
Description : Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer"s disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
Source : Mouse
Host : Human Cells
Form : Lyophilized from sterile PBS, pH7.4
Purity : > 85 % as determined by SDS-PAGE.
Endotoxin : < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70μ
Predicted N terminal : Cys 27
Molecular Mass : The recombinant mouse RTN4R/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 669 amino acids and has a predicted molecular mass of 73.8 kDa. Due to glycosylation, rmRTN4R/Fc monomer migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions.
Storage : Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Rtn4r reticulon 4 receptor [ Mus musculus ]
Official Symbol : Rtn4r
Synonyms : Rtn4r; reticulon 4 receptor; NgR; NOGOR; reticulon-4 receptor; nogo receptor; Nogo-66 receptor
Gene ID : 65079
mRNA Refseq : NM_022982
Protein Refseq : NP_075358
UniProt ID : Q99PI8
Chromosome Location : 16 B1
Function : protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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