Recombinant Human SOCS3 protein(Met1-Leu225), His&Trx-tagged
Cat.No. : | SOCS3-3895H |
Product Overview : | Recombinant Human SOCS3 (O14543) (Met 1-Leu 225) was expressed in E. coli, fused with a Trx and a polyhistide tag at the N-terminus. |
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Source : | E. coli |
Species : | Human |
Tag : | N-His&Trx |
Protein length : | Met1-Leu225 |
Form : | Lyophilized from sterile 50mM Tris, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human SOCS3/Trx fusion protein consisting of 384 amino acids and has a calculated molecular mass of 41.9 kDa. It migRates as an approximately 46 kDa band in SDS-PAGE under reducing conditions. |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | SOCS3 suppressor of cytokine signaling 3 [ Homo sapiens ] |
Official Symbol : | SOCS3 |
Synonyms : | SOCS3; suppressor of cytokine signaling 3; CIS3; Cish3; SOCS 3; SSI 3; CIS-3; STAT-induced STAT inhibitor 3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; SSI3; ATOD4; SSI-3; SOCS-3; MGC71791; |
Gene ID : | 9021 |
mRNA Refseq : | NM_003955 |
Protein Refseq : | NP_003946 |
MIM : | 604176 |
UniProt ID : | O14543 |
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SOCS3-1526R | Recombinant Rat SOCS3 Protein (1-225 aa), His-tagged | +Inquiry |
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◆ Lysates | ||
SOCS3-1580HCL | Recombinant Human SOCS3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionTherapeutic strategies for SOCS3 can include regulating its expression level, blocking its interaction with other proteins, or regulating its associated signal transduction pathways. These approaches may have potential applications in the treatment of autoimmune diseases, inflammatory diseases, and certain cancers.
The structure of SOCS3 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
In inflammatory diseases, SOCS3 may reduce the inflammatory response by inhibiting the production and release of pro-inflammatory cytokines and promoting the expression of anti-inflammatory factors. It could be a potential target for the treatment of inflammatory diseases.
This protein can interact with a variety of other proteins, including JAK kinase, STAT transcription factors, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
Drug development for SOCS3 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
SOCS3 is primarily involved in immunosuppressive and anti-inflammatory responses in the immune system. It can inhibit the production and release of pro-inflammatory cytokines and promote the expression of anti-inflammatory factors, thereby reducing the inflammatory response.
Customer Reviews (3)
Write a reviewSOCS3 is very stable in Western blot, and its performance will not be affected even if it is stored for a long time.
SOCS3 has long-lasting effects and sustained release performance.
This synthesis cost and application cost are moderate, and it is cost-effective for production.
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