"TFF3" Related Products

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Recombinant Human Trefoil Factor-3 His Tag

Cat. No.: TFF3-4169H
Product Overview: TFF3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids (22-80 a.a.) which includes a 10 amino acid His Tag fused at N-terminus and having a total molecular mass of 7.82 kDa. TFF3 Human Recombinant is purified by proprietary chromatographic techniques.
Description: Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility & secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains. TFF3 induces ciliogenesis and promotes airway epithelial ciliated cell differentiation, relatively through an epidermal growth factor receptor-dependent pathway. TFF3 overexpression is crucial for progression in mouse and human hepatocellular carcinogenesis. TFF-3 is normally expressed in hepatocellular carcinoma and its expression associates with tumor grade.
Source: Human
Host: Escherichia Coli.
Form: The TFF3 protein was lyophilized from 0.4μm filtered solution at a concentration of 0.5mg/mL containing 20mM Tris pH-7.5 and 150mM NaCl.
Purity: Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance: White lyophilized (freeze-dried) powder.
Amino acid sequence: MKHHHHHHAS EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF.
Storage: Lyophilized TFF3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TFF3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: TFF3 trefoil factor 3 (intestinal) [ Homo sapiens ]
Official Symbol: TFF3
Synonyms: TFF3; trefoil factor 3 (intestinal); ITF; TFI; HITF; hP1.B; Intestinal trefoil factor; Polypeptide P1.B; secretory protein; trefoil factor 3; trefoil factor 3, HITF, human intestinal trefoil factor; Trefoil factor 3
Gene ID: 7033
mRNA Refseq: NM_003226
Protein Refseq: NP_003217
MIM: 600633
UniProt ID: Q07654
Chromosome Location: 21q22.3
Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity

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