"TSLP" Related Products

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Recombinant Human Thymic Stromal Lymphopoietin

Cat. No.: TSLP-312H
Product Overview: Human Thymic Stromal Lymphopoietin (H-TSLP) is produced in several tissues including heart, liver and prostate. TSLP shares similar biological activities to IL-7 including enhancement of STAT3 and STAT5. TSLP induces the release of T-cell chemokines from monocytes and affects increased growth of dendritic cells. H-TSLP is also signals through the IL-7 receptor and TSLP-R receptor pathways. H-TSLP is comprised of 132 amino acids with a molecular weight of 15,000 Da.
Description: Thymic Stromal Lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells.TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells. These cells are located in regions where TSLP activity is required.
Species: Human
Source: E.coli
Form: Lyophilized from 10 mM NaP, 7.5.
Purity: Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity: Currently not available.
Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 97% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by: UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level: Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence: MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLL KQQ
Storage: Lyophilized product is very stable at -20°C. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Gene Name: TSLP thymic stromal lymphopoietin [ Homo sapiens ]
Official Symbol: TSLP
Synonyms: TSLP; thymic stromal lymphopoietin; Thymic stromal lymphopoietin Precursor; OTTHUMP00000158998; OTTHUMP00000158999
Gene ID: 85480
mRNA Refseq: NM_033035
Protein Refseq: NP_149024
MIM: 607003
UniProt ID: Q969D9
Chromosome Location: 5q22.1
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; protein binding

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