Recombinant Human VEGFA protein, His-tagged
Cat.No. : | VEGFA-584H |
- Specification
- Gene Information
- Related Products
Product overview : | Recombinant Human VEGFA (P15692) aa. (Pro28~Arg147) fused with His tag was produced in E. coli cells. |
Description : | This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 18.2kDa; Accurate Molecular Mass: 17&18kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Pro28~Arg147 |
Purity : | >98% |
Characteristic : | Isoelectric point is 6.3. |
Applications : | Cell culture; Activity Assays. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 0.05% sarcosyl and 5% trehalose. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex |
Gene Name : | VEGFA vascular endothelial growth factor A [ Homo sapiens (human) ] |
Official Symbol : | VEGFA |
Synonyms : | VEGFA; VPF; VEGF; MVCD1; vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular permeability factor |
Gene ID : | 7422 |
mRNA Refseq : | NM_001025366.2 |
Protein Refseq : | NP_001020537.2 |
UniProt ID : | P15692 |
Products Types
◆ Recombinant Protein | ||
VEGFA-22H | Active Recombinant Human VEGFA Protein, Pre-aliquoted | +Inquiry |
Vegfa-327M | Recombinant Active Mouse VEGFA (VEGF121) Protein, His-tagged(C-ter) | +Inquiry |
VEGFA-326H | Recombinant Active Human VEGFA (VEGF121) Protein, His-tagged(C-ter) | +Inquiry |
VEGFA-35H | Recombinant Human VEGFA Protein, Fc-tagged | +Inquiry |
VEGFA-4373C | Recombinant Chicken VEGFA Protein | +Inquiry |
◆ Lysates | ||
VEGFA-727HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
VEGFA-522RCL | Recombinant Rat VEGFA cell lysate | +Inquiry |
VEGFA-1427HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that there is an association between the expression level of VEGFA protein and other biomarkers, for example, it can be associated with indicators such as tumor cell differentiation, metastatic capacity, and prognosis.
At present, a variety of drugs have been developed to target the VEGFA protein and its related signaling pathway, including inhibiting its expression and inhibiting its binding to receptors, etc., for the treatment of tumors and other vascular-related diseases.
VEGFA protein plays a key role in tumor angiogenesis, promoting tumor growth and metastasis by stimulating endothelial cell proliferation, migration, and vascular network formation.
The expression of VEGFA protein in different tissues and organs is different, and it is expressed in tumor tissue, cardiovascular system and other tissues and organs, and the expression level may be affected by many factors.
Studies have shown that the expression level of VEGFA protein is related to the degree of malignancy of the tumor, and the high expression of VEGFA protein often indicates that the tumor is more aggressive.
VEGFA protein plays an important role in cardiovascular disease by regulating endothelial cell function, promoting vascular repair and maintaining cardiovascular system homeostasis.
Customer Reviews (2)
Write a reviewVEGFA's catalytic activity is so strong that it can adapt even in the face of complex chemical reactions.
VEGFA they produced was highly active and the experimental effect was obvious.
Ask a Question for All VEGFA Products
Required fields are marked with *
My Review for All VEGFA Products
Required fields are marked with *
Inquiry Basket