"MMP13" Related Products

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Recombinant Human MMP13

Cat. No.: MMP13-1018H
Product Overview: Matrix Metalloproteinase-13 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 27 kDa. The Collagenase 3 is purified by proprietary chromatographic techniques.
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Source: E. coli
Species: Human
Form: The protein Solution (100 µg/ml) in 0.05 M Tris-HCl buffer, pH 7.6, containing 0.2 M NaCl, 5 mM CaCl2, 20 µM ZnSO4 and 0.1% BSA and NaN3.
Research topic: Energy metabolism and body weight regulation
Purity: >90%
Storage: MMP-13 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: MMP13 matrix metallopeptidase 13 (collagenase 3) [ Homo sapiens ]
Official Symbol: MMP13
Synonyms: MMP13; matrix metallopeptidase 13 (collagenase 3); CLG3; MANDP1; collagenase 3; MMP-13; OTTHUMP00000231260; OTTHUMP00000231261; matrix metalloproteinase 13 (collagenase 3)
Gene ID: 4322
mRNA Refseq: NM_002427
Protein Refseq: NP_002418
MIM: 600108
UniProt ID: P45452
Chromosome Location: 11q22
Pathway: Endochondral Ossification; Matrix Metalloproteinases
Function: calcium ion binding; calcium-dependent protein binding; fibronectin binding; low-density lipoprotein particle receptor binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

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