Active Recombinant Human DPP4, His-tagged
Cat.No. : | DPP4-1081H |
Product Overview : | Human DPP4 (NP_001926, 39 a.a. - 766 a.a.) partial recombinant protein with His tag expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | DPP4-1081H |
Description : | DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction, apoptosis and plays an important role in tumor biology. |
Sequence : | ADP-R KTYTLTDYLK NTYRLKLYSL RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH SINDYSISPD GQFILLEYNY VKQWRHSYTA SYDIYDLNKR QLITEERIPN NTQWVTWSPV GHKLAYVWNN DIYVKIEPNL PSYRITWTGK EDIIYNGITD WVYEEEVFSA YSALWWSPNG TFLAYAQFND TEVPLIEYSF YSDESLQYPK TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT NATSIQITAP ASMLIGDHYL CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL VARQHIEMST TGWVGRFRPS EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG TWEVIGIEAL TSDYLYYISN EYKGMPGGRN LYKIQLSDYT KVTCLSCELN PERCQYYSVS FSKEAKYYQL RCSGPGLPLY TLHSSVNDKG LRVLEDNSAL DKMLQNVQMP SKKLDFIILN ETKFWYQMIL PPHFDKSKKY PLLLDVYAGP CSQKADTVFR LNWATYLAST ENIIVASFDG RGSGYQGDKI MHAINRRLGT FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL GSGSGVFKCG IAVAPVSRWE YYDSVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY LLIHGTADDN VHFQQSAQIS KALVDVGVDF QAMWYTDEDH GIASSTAHQH IYTHMSHFIK QCFSLP-SGRLVPRGSHHHHHH |
Theoretical MW (kDa) : | 86.40000000000001 |
Form : | Liquid |
Preparation Method : | E. coli expression system |
Purity : | > 95% by SDS-PAGE |
Endotoxin Level : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Activity : | Approximately > 50 Unit/mg. One unit will hydrolyze 1 umole of p-nitroaniline per minute at pH 8.0 at 37°C using 1mM of Gly-Pro p-nitroanilde as a substrate. |
Application : | SDS-PAGE |
Storage Buffer : | In 20 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 8.0 (10% glycerol) |
Storage : | Store at 4°C for 1-2 weeks. For long term storage store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing. |
Unitprot ID : | P27487 |
Gene Name : | DPP4 dipeptidyl-peptidase 4 [ Homo sapiens ] |
Official Symbol : | DPP4 |
Synonyms : | ADABP; ADCP2; CD26; DPPIV; EC 3.4.14.5; TP103; Adenosine deaminase complexing protein 2; CD26 antigen; DPP IV; Dipeptidyl peptidase IV; T-cell activation antigen CD26; dipeptidyl-peptidase 4; dipeptidylpeptidase 4; dipeptidylpeptidase IV; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP4 |
Gene ID : | 1803 |
mRNA Refseq : | NM_001935 |
Protein Refseq : | NP_001926 |
MIM : | 102720 |
Chromosome Location : | 2q24.3 |
Function : | aminopeptidase activity; dipeptidyl-peptidase activity; protein binding; homodimerization activity; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
DPP4-1602R | Recombinant Rat DPP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Dpp4-2641M | Recombinant Mouse Dpp4 Protein, Myc/DDK-tagged | +Inquiry |
DPP4-792H | Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
DPP4-2844H | Recombinant Human DPP4 Protein | +Inquiry |
DPP4-608H | Active Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
DPP4-31H | Active Native Human DPP4 | +Inquiry |
DPP4-197H | Native Human Dipeptidyl Peptidase IV | +Inquiry |
◆ Lysates | ||
DPP4-2979HCL | Recombinant Human DPP4 cell lysate | +Inquiry |
DPP4-733CCL | Recombinant Cynomolgus DPP4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0314 | DPP4 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0317 | DPPIV/CD26 Assay Kit | +Inquiry |
Kit-0313 | DPP IV Immunocapture Activity Assay Kit | +Inquiry |
Kit-0312 | Dipeptidyl peptidase IV Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.
Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.
Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.
DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.
DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.
Customer Reviews (3)
Write a reviewIts purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.
By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.
Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.
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