| Cat. No. : |
IL13-328H |
| Description : |
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. In addition to effects on immune cells that are similar to those of the closely related cytokine IL-4, IL-13 is more importantly implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rμ) and at least one of two known IL-13-specific binding chains. |
| Sequence : |
SP GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN |
| Theoretical MW (kDa) : |
13 |
| Form : |
Lyophilized |
| Preparation Method : |
Escherichia coli expression system |
| Purity : |
> 95% by SDS-PAGE and HPLC |
| Endotoxin Level : |
< 0.1 ng/ug (1 EU/ug) |
| Activity : |
The ED50 was determined by the dose-dependent proliferation of TF-1 cells was μ2.0 ng/mL, corresponding to a specific activity of μ 1 x 106units/mg. |
| Application : |
SDS-PAGE |
| Storage Buffer : |
Lyophilized from PBS, pH 7.2 |
| Storage : |
Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing. |
| Unitprot ID : |
P35225 |
| Pathways : |
Asthma; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway |
