| Cat. No. : |
IL1B-339H |
| Description : |
Interleukin-1 beta (IL-1μ) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1μ precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1μ. IL-1μ is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. |
| Sequence : |
APVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS |
| Theoretical MW (kDa) : |
17 |
| Form : |
Lyophilized |
| Preparation Method : |
Escherichia coli expression system |
| Purity : |
> 97% by SDS-PAGE and HPLC |
| Endotoxin Level : |
< 0.1 ng/ug (1 EU/ug) |
| Activity : |
The ED50 as determined by the dose-dependent proliferation of murine D10S cells, was found to be μ2.0 pg/ml, corresponding to a specific activity of μ2 x 109 units/mg. |
| Application : |
SDS-PAGE |
| Storage Buffer : |
Lyophilized from PBS, pH 7.0 |
| Storage : |
Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing. |
| Unitprot ID : |
P01584 |
| Pathways : |
Alzheimer"s disease; Apoptosis; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus. |
