||Soluble Receptor Activator of NFĸB Ligand (sRANKL) Mouse Recombinant produced in E.coli is single, non-glycosylated, polypeptide chain containing 179 amino acids and having a total molecular mass of 19.9 kDa. CD254 is purified by proprietary chromatographic techniques.
||Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.
||The protein (1 mg/ml) was lyophilized with 10mM NaP, pH 7.5 + 50 NaCl.
||Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE
|Sequences of amino acids:
||PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID
||Lyophilized rec. Human sRANKL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHu sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
||Cytokine-cytokine receptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclast differentiation; Rheumatoid arthritis