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Active Recombinant Human TGFA

Cat.No. : TGFA-538H
Product Overview : Human TGFA (P01135) full-elngth recombinant protein expressed in Hi-5 cells.
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  • Gene Information
  • Related Products
Cat. No. : TGFA-538H
Description : Transforming growth factor alpha (TGF-μ) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFμ stimulates neural cell proliferation in the adult injured brain.
Theoretical MW (kDa) : 25
Form : Lyophilized
Preparation Method : Insect cell (Hi-5) expression system
Purity : μ 98% by SDS-PAGE, μ 98% by HPLC
Endotoxin Level : < 0.1 ng/ug
Activity : The ED50 as determined by the ability of TGF-beta2 to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is < 0.2 ng/mL, corresponding to a specific activity of > 5 x 106 units/mg.
Application : SDS-PAGE
Storage Buffer : Lyophilized from sodium citrate, pH 3.5
Storage : Store at -20°C on dry atmosphere.
Unitprot ID : P01135
Gene Name : TGFA transforming growth factor, alpha [ Homo sapiens ]
Official Symbol : TGFA
Synonyms : TGFA; transforming growth factor, alpha; TFGA; protransforming growth factor alpha; transforming growth factor-alpha; TGF-alpha; EGF-like TGF; TGF type 1; ETGF
Gene ID : 7039
mRNA Refseq : NM_001099691
Protein Refseq : NP_001093161
MIM : 190170
Chromosome Location : 2p13
Pathway : ErbB signaling pathway; Glioma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
Function : MAP kinase kinase activity; epidermal growth factor receptor binding; growth factor activity; protein binding; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does TGFA contribute to cell growth and proliferation? 05/10/2022

It stimulates cell proliferation and survival, playing a key role in tissue development.

How do genetic variations in TGFA affect tissue repair? 12/27/2020

Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.

What is the impact of altered TGFA activity on cancer development? 11/09/2019

Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.

What is the primary role of TGFA in cell signaling? 01/29/2018

TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.

What potential therapeutic applications arise from targeting TGFA in regenerative medicine and oncology? 06/22/2017

Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.

How does TGFA interact with other growth factors and receptors? 06/12/2017

TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.

What role does TGFA play in wound healing? 03/14/2017

TGFA is important in wound healing, promoting the regeneration of skin and other tissues.

Customer Reviews (3)

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Reviews
05/03/2020

    Swift and accurate service, essential for research success.

    04/14/2020

      Invaluable support for insights, a research cornerstone.

      12/21/2018

        Trustworthy results, supports research consistency.

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