Active Recombinant Mouse Csf1 (33-262aa), Met tagged
Cat.No. : | Csf1-041E |
Product Overview : | Recombinant Mouse Csf1 (Lys33 Glu262, with an Nterminal Met ) was expressed in E. coli and produced using nonanimal reagent in an animalfree laboratory. |
- Specification
- Gene Information
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Cat. No. : | Csf1-041E |
Description : | MCSF, also known as CSF1, is a fourμhelical bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. MCSF is also essential for the survival and proliferation of osteoclast progenitors. MCSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis . MCSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of MCSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. |
Source : | E. coli |
Nterminal Sequence Analysi : | Met |
Structure / Form : | Disulfidelinked homodimer |
Molecular Mass : | 26 kDa (monomer) |
SDSPAGE : | 52 kDa, nonreducing conditions |
Activity : | Measured in a cell proliferation assay using MNFS60 mouse myeloid cells. The ED50 for this effect is typically 0.5 3 ng/mL. |
Endotoxin Leve : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Formulation : | Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details. |
Reconstitution : | Reconstitute at 200 μg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Storage : | Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, 20 to 70 °C under sterile conditions after reconstitution. |
Gene Name : | Csf1 colony stimulating factor 1 (macrophage) [ Mus musculus ] |
Official Symbol : | Csf1 |
Synonyms : | Csf1; colony stimulating factor 1 (macrophage); op; Csfm; MCSF; C87615; macrophage colony-stimulating factor 1; osteopetrosis |
Gene ID : | 12977 |
mRNA Refseq : | NM_001113530 |
Protein Refseq : | NP_001107002 |
UniProt ID : | P07141 |
Chromosome Location : | 3 F3; 3 51.0 cM |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Osteoclast differentiation; Rheumatoid arthritis; Signaling events mediated by PTP1B; Signaling events mediated by TCPTP |
Function : | cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding; protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
Csf1-46M | Recombinant Active Mouse CSF1 Protein, His-tagged(C-ter) | +Inquiry |
CSF1-5383H | Recombinant Human Colony Stimulating Factor 1 (macrophage) | +Inquiry |
CSF1-2158H | Recombinant Human CSF1 Protein, His-tagged | +Inquiry |
Csf1-1107M | Recombinant Mouse Csf1 Protein, His-tagged | +Inquiry |
CSF1-083C | Active Recombinant Human CSF1 Protein (1-149 aa) | +Inquiry |
◆ Lysates | ||
CSF1-1934HCL | Recombinant Human CSF1 cell lysate | +Inquiry |
CSF1-001MCL | Recombinant Mouse CSF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.
Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.
Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.
Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.
Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewThe CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.
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