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Active Recombinant Mouse Csf1 (33-262aa), Met tagged

Cat.No. : Csf1-041E
Product Overview : Recombinant Mouse Csf1 (Lys33 ­ Glu262, with an N­terminal Met ) was expressed in E. coli and produced using non­animal reagent in an animal­free laboratory.
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Cat. No. : Csf1-041E
Description : M­CSF, also known as CSF­1, is a four­μ­helical­ bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M­CSF is also essential for the survival and proliferation of osteoclast progenitors. M­CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis . M­CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M­CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells.
Source : E. coli
N­terminal Sequence Analysi : Met
Structure / Form : Disulfide­linked homodimer
Molecular Mass : 26 kDa (monomer)
SDS­PAGE : 52 kDa, non­reducing conditions
Activity : Measured in a cell proliferation assay using M­NFS­60 mouse myeloid cells. The ED50 for this effect is typically 0.5 ­ 3 ng/mL.
Endotoxin Leve : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Reconstitution : Reconstitute at 200 μg/mL in sterile PBS.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage : Use a manual defrost freezer and avoid repeated freeze­thaw cycles. 1. 12 months from date of receipt, ­20 to ­70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Gene Name : Csf1 colony stimulating factor 1 (macrophage) [ Mus musculus ]
Official Symbol : Csf1
Synonyms : Csf1; colony stimulating factor 1 (macrophage); op; Csfm; MCSF; C87615; macrophage colony-stimulating factor 1; osteopetrosis
Gene ID : 12977
mRNA Refseq : NM_001113530
Protein Refseq : NP_001107002
UniProt ID : P07141
Chromosome Location : 3 F3; 3 51.0 cM
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Osteoclast differentiation; Rheumatoid arthritis; Signaling events mediated by PTP1B; Signaling events mediated by TCPTP
Function : cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CSF1 affect cancer progression? 09/20/2022

CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

What are the potential side effects of CSF1 therapy? 07/11/2022

Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

Can CSF1 therapy be combined with other treatments? 08/26/2020

Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

What are the challenges in developing CSF1-based therapies? 09/26/2019

Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

In what ways is CSF1 being researched for neurological disorders? 10/01/2018

Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.

Customer Reviews (3)

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Reviews
10/30/2017

    The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

    03/10/2017

      With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

      06/09/2016

        Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

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