"PPP1CA" Related Products

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Recombinant Human PPP1CA, His-tagged

Cat. No.: PPP1CA-1015H
Product Overview: Recombinant human PPP1CA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography (1-330 aa).
Description: PPP1CA, also known as serine/threonine-protein phosphatase PP1-alpha catalytic subunit, is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. This protein may play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.
Form: Liquid. 50mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT, 0.1mM PMSF, 1mM MnCl2
Molecular Weight: 39.7 kDa (350aa), confirmed by MALDI-TOF
Purity: > 80% by SDS - PAGE
Concentration: 0.25 mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: ALK1 signaling events; BMP receptor signaling; DARPP-32 events; Focal adhesion; Insulin signaling pathway; Lipid digestion, mobilization, and transport; Long-term potentiation; Metabolism of lipids and lipoproteins; Oocyte meiosis; Opioid Signalling; Regulation of actin cytoskeleton
Gene Name: PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme [ Homo sapiens ]
Official Symbol: PPP1CA
Synonyms: PPP1CA; PP-1A; PPP1A; MGC1674; MGC15877; PP1alpha; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; OTTHUMP00000236398; OTTHUMP00000236399; OTTHUMP00000236400; OTTHUMP00000236401; protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; EC 3.1.3.16
Gene ID: 5499
mRNA Refseq: NM_001008709
Protein Refseq: NP_001008709
MIM: 176875
UniProt ID: P62136
Chromosome Location: 11q13
Function: hydrolase activity; metal ion binding; protein binding; protein phosphatase type 1 regulator activity; protein serine/threonine phosphatase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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