Recombinant Human Pro-opiomelanocortin, His-tagged
Cat.No. : | POMC-3548H |
Product Overview : | Recombinant human POMC protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | POMC-3548H |
Description : | Pro-opiomelanocortin preproprotein, also known as POMC, a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. It regulates the corticosteroid production in the adrenal cortex. Also, POMC is cleaved into ten hormone chains named NPP, μ-MSH, ACTH, μ-MSH, CLIP, Lipotropin μ, Lipotropin μ, μ-MSH, μ endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. |
Source : | E. coli. |
Purity : | > 85% by SDS - PAGE |
Formulation : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl. |
Molecular Weight : | 28.9 kDa (262aa), confirmed by MALDI-TOF(molecular weight on SDS-PAGE will appear higher) |
Concentration : | 0.25mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MWCLESSQCQ DLTTESNLLE CIRACKPDLS AETPMFPGNG DEQPLTENPR KYVMGHFRWD RFGRRNSSSSGSSGAGQKRE DVSAGEDCGP LPEGGPEPRS DGAKPGPREG KRSYSMEHFR WGKPVGKKRR PVKVYPNGAE DESAEAFPLE FKRELTGQRL REGDGPDGPA DDGAGAQADL EHSLLVAAEK KDEGPYRMEH FRWGSPPKDK RYGGFMTSEK SQTPLVTLFK NAIIKNAYKK GE |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | POMC proopiomelanocortin [ Homo sapiens ] |
Synonyms : | ACTH; adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte-stimulating hormone; alpha-MSH; beta-endorphin; beta-lipotropin; beta-LPH; beta-melanocyte-stimulating hormone; beta-MSH; CLIP; corticotropin-like intermediary peptide; Corticotropin-lipotropin; gamma-LPH; gamma-MSH; lipotropin beta; lipotropin gamma; LPH; melanotropin alpha; melanotropin beta; melanotropin gamma; met-enkephalin; MSH; NPP; OTTHUMP00000200965; POC; POMC; pro-ACTH-endorphin; proopiomelanocortin; pro-opiomelanocortin; proopiomelanocortin preproprotein; proopiomelanocortin1 |
Gene ID : | 5443 |
mRNA Refseq : | NM_001035256 |
Protein Refseq : | NP_001030333 |
MIM : | 176830 |
UniProt ID : | P01189 |
Chromosome Location : | 2p23.3 |
Pathway : | Adipocytokine signaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; G alpha (s) signalling events; G-protein activation; GPCR downstream signaling; GPCR ligand binding; Glucocorticoid receptor regulatory network; Melanogenesis; Metabolism of amino acids and derivatives; Opioid Signalling; Peptide hormone biosynthesis; Peptide ligand-binding receptors; Signaling by GPCR; Syndecan-3-mediated signaling events. |
Function : | G-protein-coupled receptor binding; receptor binding; hormone activity; type 1 melanocortin receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding |
Products Types
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◆ Lysates | ||
POMC-3018HCL | Recombinant Human POMC 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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