"Casp3" Related Products

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Recombinant Rat Caspase 3

Cat. No.: Casp3-1644R
Product Overview: Recombinant active human Casp3 expressed in E. coli.
Description: Casp3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. Casp3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B.
Biological Activity: 300000 units/mg
Molecular Weight: large (17 kD) and small (11 kD) subunits
Source: E. coli
Species: Human
Form: Lyophilized powder.
Appearance: Lyophilized powder
Reconstitution: Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Storage: The lyophilized caspase-3 is stable for 1 year at -70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at -70°C. Avoid multiple freeze/thaw cycles as activity might decrease.
Pathways: ATM; Activation of DNA fragmentation factor; Alpha6-Beta4 Integrin Signaling Pathway; Alzheimer"s disease; Amoebiasis; Amyotrophic lateral sclerosis (ALS); Androgen Receptor Signaling Pathway; Apoptosis; Apoptosis Modulation by HSP70; Apoptotic cleavage of cell adhesion proteins; Apoptotic execution phase; Cardiovascular Signaling; Colorectal cancer; Herpes simplex infection; Legionellosis; MAPK signaling pathway
Gene Name: Casp3 caspase 3 [ Rattus norvegicus ]
Official Symbol: Casp3
Synonyms: Casp3; caspase 3; Lice; MGC93645; caspase-3; IRP; SCA-1; CASP-3; CPP-32; apopain; CPP32beta; protein Yama; yama protein; cysteine protease CPP32; SREBP cleavage activity 1; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); Caspase-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; LICE; Protein Yama
Gene ID: 25402
mRNA Refseq: NM_012922
Protein Refseq: NP_037054
UniProt ID: P55213
Chromosome Location: 16q11
Function: aspartic-type endopeptidase activity; cyclin-dependent protein kinase inhibitor activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; phospholipase A2 activator activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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