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Recombinant Human Vascular Endothelial Growth Factor C, His-tagged

Cat.No. : VEGFC-615H
Product Overview : The recombinant human protein contains N-terminal and C-terminal His-tags (167 aa, MW 18.772 kDa).
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Cat. No. : VEGFC-615H
Description : The recombinant VEGFC (Vascular Endothelial Growth Factor-C) lacks the N-terminal signal peptide and includes amino acids from T103 to R227 of Gene Bank U58111.
Biological Activity : Activity of VEGFC is tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED50 is > 200 ng/ml.
Molecular Weight : 18.772 kDa
Source : E. coli
Species : Human
Form : Lyophilized without additives.
Appearance : Lyophilized protein
Endotoxin Level : <0.1 ng/μg
Reconstitution : We recommend a quick spin followed by reconstitution in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
Purity : >90% by SDS-PAGE analyses.
Storage : The lyophilized VEGFC is best-stored at -20°C. Reconstituted VEGFC should be stored in working aliquots at -70°C.
Pathways : Bladder cancer; Cytokine-cytokine receptor interaction; Focal Adhesion; Focal adhesion; Formation of Platelet plug; Heart Development; Hemostasis; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; Response to elevated platelet cytosolic Ca2+; Signaling by VEGF; Signaling events mediated by VEGFR1 and VEGFR2; VEGF ligand-receptor interactions; VEGFR3 signaling in lymphatic endothelium; mTOR signaling pathway
Gene Name : VEGFC vascular endothelial growth factor C [ Homo sapiens ]
Official Symbol : VEGFC
Synonyms : VEGFC; vascular endothelial growth factor C; RP; Flt4-L; VEGF-C; FLT4 ligand DHM; OTTHUMP00000218843; vascular endothelial growth factor-related protein; VRP; Flt4 ligand
Gene ID : 7424
mRNA Refseq : NM_005429
Protein Refseq : NP_005420
MIM : 601528
UniProt ID : P4976
Chromosome Location : 4q34.3
Function : chemoattractant activity; growth factor activity; protein binding; vascular endothelial growth factor receptor 3 binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What signaling mechanisms are involved in VEGFC and its receptor interactions? 05/21/2022

VEGFC primarily signals through its interactions with VEGFR-2 (Vascular Endothelial Growth Factor Receptor 2) and VEGFR-3. Upon binding to one of these receptors, VEGFC triggers receptor dimerization, leading to the activation of intracellular signaling pathways. This activation involves phosphorylation events and subsequent recruitment of downstream effectors, which ultimately regulate cellular responses such as proliferation, migration, and angiogenesis. The intricate signaling mechanisms underlying VEGFC-receptor interactions contribute to its functional versatility and provide potential targets for therapeutic interventions.

What is known about the structural characteristics of VEGFC and its precursor? 03/29/2022

VEGFC protein is derived from the conversion of proVEGFC precursor protein and comprises approximately 354 amino acid residues. Structurally, it consists of a signal sequence, an N-terminal domain, and a C-terminal VEGF homology domain. The signal sequence is involved in cellular localization and secretion processes, while the VEGF homology domain interacts with target receptors, mediating cellular proliferation and angiogenesis. Understanding the specific structural features is crucial for elucidating the functional properties and molecular interactions associated with VEGFC.

How does VEGFC contribute to pathological conditions, particularly in cancer? 12/06/2021

VEGFC's involvement in pathological conditions, including cancer, is extensively studied. The upregulation of VEGFC expression in tumor cells promotes angiogenesis and lymphangiogenesis within the tumor microenvironment. This enhanced blood and lymphatic vessel formation facilitates tumor growth, invasion, and metastasis. Moreover, VEGFC can induce lymphangiogenesis in sentinel lymph nodes, aiding cancer cell dissemination. Targeting VEGFC signaling pathways has emerged as a potential therapeutic strategy to inhibit tumor angiogenesis and lymphangiogenesis, highlighting the clinical significance of understanding the complex interplay between VEGFC and cancer progression.

What are the current therapeutic interventions targeting VEGFC and its downstream signaling pathways? 04/22/2021

Several therapeutic interventions targeting VEGFC and its downstream signaling pathways are under investigation. Anti-VEGFC monoclonal antibodies, VEGFR inhibitors, and small molecule inhibitors of VEGFC-mediated signaling have shown promise in preclinical and clinical studies. These interventions aim to disrupt the angiogenic and lymphangiogenic processes driven by VEGFC, thereby inhibiting tumor growth, metastasis, and other pathological conditions associated with VEGFC dysregulation. Additionally, exploring combinational approaches with existing therapies, such as chemotherapy and immunotherapy, holds potential for synergistic effects and improved treatment outcomes. Continued research efforts are focused on optimizing these interventions for clinical application and expanding the therapeutic repertoire for VEGFC-associated diseases.

Are there any known regulatory mechanisms that modulate VEGFC expression levels? 08/20/2020

Multiple regulatory mechanisms control VEGFC expression levels. Transcriptional regulation plays a significant role, with various transcription factors binding to the VEGFC promoter region to activate or suppress its transcription. Additionally, post-transcriptional regulation through microRNAs and RNA-binding proteins can modulate VEGFC mRNA stability and translation efficiency. Furthermore, environmental factors, such as hypoxia and inflammation, influence VEGFC expression by activating specific signaling pathways. Understanding the precise regulatory mechanisms is crucial for deciphering the intricate balance required for maintaining proper VEGFC levels and ensuring its functional integrity.

What are the clinical implications of VEGFC dysregulation? 05/08/2020

Dysregulation of VEGFC has been associated with various pathological conditions. Excessive VEGFC expression has been implicated in tumor angiogenesis, promoting the growth and spread of cancer cells by stimulating the formation of blood and lymphatic vessels in the tumor microenvironment. On the other hand, decreased or insufficient VEGFC levels have been linked to lymphatic disorders, such as lymphedema, where impaired lymphatic vessel development results in fluid buildup and tissue swelling. Additionally, alterations in VEGFC signaling have been observed in ocular diseases, inflammatory disorders, and cardiovascular diseases. Understanding the dysregulation of VEGFC in these contexts may pave the way for potential therapeutic strategies targeting this protein.

What are the cellular functions of VEGFC and its involvement in physiological processes? 05/30/2017

VEGFC (Vascular Endothelial Growth Factor C) has diverse cellular functions. Primarily, it serves as a potent angiogenic factor, participating in neovascularization and lymphangiogenesis processes. VEGFC also regulates endothelial cell proliferation and migration, playing a crucial role in lymphatic dissemination and metastasis. Additionally, VEGFC is implicated in neurodevelopment, mammary gland morphogenesis, tissue regeneration, and other physiological processes. Its multifaceted functions highlight its significance in various biological contexts, emphasizing the need for further investigation to unravel its precise mechanisms and implications.

Customer Reviews (3)

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Reviews
02/12/2021

    Embodied with the glorious power of scientific progress, the innovation behind this reagent inspires truly remarkable experimental encounters.

    02/21/2018

      By requiring minimal usage, this protein reagent significantly reduces consumable costs, making it an ideal choice for large-scale experiments.

      03/26/2016

        The manufacturer's proactive approach in offering valuable insights and suggestions has greatly improved the outcome of my experiments.

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