"Vegfc" Related Products


Recombinant Rat Vascular Endothelial Growth Factor C

Cat. No. : Vegfc-616R
Product Overview : Vegfc (Vascular Endothelial Growth Factor-C) is a 125 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain.
Description : The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors.
Biological Activity : Activity of Vegfc will be tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED₅₀ is > 200 ng/ml.
Molecular Weight : 15.0 kDa
Source : E. coli
Species : Rat
Form : Lyophilized without additives.
Appearance : Lyophilized protein
Endotoxin Level : <0.1 ng/μg
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
Purity : >90% by SDS-PAGE analyses.
Storage : The lyophilized Vegfc is best-stored at -20°C. Reconstituted Vegfc should be stored in working aliquots at -70°C.
Pathways : Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Formation of Platelet plug; Hemostasis; Pancreatic cancer; Pathways in cancer; Platelet degranulation; Renal cell carcinoma; Response to elevated platelet cytosolic Ca2+; Signaling by VEGF; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; mTOR signaling pathway
Gene Name : Vegfc vascular endothelial growth factor C [ Rattus norvegicus ]
Official Symbol : Vegfc
Synonyms : Vegfc; vascular endothelial growth factor C; VRP; VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-related protein
Gene ID : 114111
mRNA Refseq : NM_053653
Protein Refseq : NP_446105
UniProt ID : O35757
Chromosome Location : 16p11
Function : chemoattractant activity; growth factor activity; vascular endothelial growth factor receptor 3 binding

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