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Recombinant Human BMP7 protein

Cat.No. : BMP7-03H
Product Overview : Recombinant Human BMP7 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : Bone Morphogenetic Protein 7 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP-7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP-7 is synthesized with a signal sequence (29 a.a.), a propeptide (263 a.a.), and a growth factor domain (139 a.a.). The growth factor domain of human BMP-7 shares 98 % a.a. sequence identity with mouse and rat BMP-7.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in 30 % acetonitrile, 0.1 % TFA.
Molecular Mass : Approximately 15.7 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids.
Protein length : 139
AA Sequence : STGSKQRSQNRSKTPKNQEALRMAN VAENSSSDQRQACKKHELYVSFRDL GWQDWIIAPEGYAAYYCEGECAFPL NSYMNATNHAIVQTLVHFINPETVP KPCCAPTQLNAISVLYFDDSSNVIL KKYRNMVVRACGCH
Endotoxin : Less than 1 EU/μg of rHuBMP-7 as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Applications : Molecular standard (Western, ELISA) in studying secreted BMP-7; Preparing antibodies for BMP-7 monomer; Molecule standard in detecting secreted BMP-7 in reduced SDS-PAGE.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10 mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : BMP7
Official Symbol : BMP7
Synonyms : BMP7; bone morphogenetic protein 7; OP 1; osteogenic protein 1; BMP-7; OP-1;
Gene ID : 655
mRNA Refseq : NM_001719
Protein Refseq : NP_001710
MIM : 112267
UniProt ID : P18075

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential side effects or risks associated with BMP7 treatment? 01/31/2023

Yes, potential side effects include inflammation, swelling, and in rare cases, excessive bone growth.

How does BMP7 contribute to bone healing? 03/08/2022

BMP7 stimulates the differentiation of mesenchymal stem cells into osteoblasts, promoting bone formation and repair.

Can BMP7 be used in spinal fusion surgeries? 05/13/2021

Yes, BMP7 is often used in spinal fusion surgeries to stimulate bone growth and enhance the fusion process.

In what medical conditions is BMP7 protein commonly used? 02/08/2018

BMP7 is commonly used in conditions such as bone fractures, spinal fusions, and non-union fractures.

Is BMP7 exclusively used in orthopedic applications? 01/13/2017

While orthopedics is a primary application, BMP7 is also being explored for its potential in treating kidney and eye disorders.

Customer Reviews (3)

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Reviews
01/08/2022

    By incorporating the BMP7 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.

    04/26/2021

      Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function

      05/13/2017

        The BMP7 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.

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