"HDAC3" Related Products

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Recombinant Human Histone Deacetylase 3, GST-tagged

Cat. No.: HDAC3-1591H
Product Overview: Full-length recombinant human HDAC3 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Description: HDAC3 or Histone deacetylase 3 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC3 may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis.
Applications: HDAC Assay; Western Blot
Molecular Weight: 83 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity: >70%
Concentration: 0.1 ug/ul
Specific Activity: 125 RLU/min/ng
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Cell cycle; Diabetes pathways; Fatty acid, triacylglycerol; Metabolism of lipids and lipoproteins; Regulation of retinoblastoma protein; Retinoic acid receptors-mediated signaling; Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class II; Signalling by NGF; Transcriptional Regulation of White Adipocyte Differentiation; Validated targets of C-MYC transcriptional repression; p75 NTR receptor-mediated signaling; p75NTR negatively regulates cell cycle via SC1
Gene Name: HDAC3 histone deacetylase 3 [ Homo sapiens ]
Official Symbol: HDAC3
Synonyms: HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; OTTHUMP00000160029
Gene ID: 8841
mRNA Refseq: NM_003883
Protein Refseq: NP_003874
MIM: 605166
UniProt ID: O15379
Chromosome Location: 5q31.1-q31
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; transcription factor binding; chromatin binding; DNA binding; protein deacetylase activity; transcription corepressor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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