Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, F, GST-tagged

• Cat.No.: PTPRF-1624H
• Product Overview: Recombinant human PTPRF (1275-1897) was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Cat. No.: PTPRF-1624H
• Description: PTPRF is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
• Applications: Phosphatase Assay; Western Blot
• Molecular Weight: 93 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 454 nmol/min/mg
• Purity: > 90 %
• Concentration: 0.1 ug/ul
• Sequences: 1275-1897
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Adherens junction; Cell adhesion molecules (CAMs); Insulin Signaling; Insulin signaling pathway

Gene Information

• Gene Name: PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
• Official Symbol: PTPRF
• Synonyms: PTPRF; protein tyrosine phosphatase, receptor type, F; LAR; FLJ43335; FLJ45062; FLJ45567; receptor-type tyrosine-protein phosphatase F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; OTTHUMP00000008687; OTTHUMP00000008688; OTTHUMP00000192913; OTTHUMP00000192914; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine phosphatase, receptor type, F polypeptide; EC 3.1.3.48; Receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related
• Gene ID: 5792
• mRNA Refseq: NM_002840
• Protein Refseq: NP_002831
• MIM: 179590
• UniProt ID: P10586
• Chromosome Location: 1p34
• Function: hydrolase activity; insulin receptor binding; phosphate binding; protein tyrosine phosphatase activity; receptor activity; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine phosphatase activity