"GSR" Related Products

Expand
Expand
Expand

Recombinant Human Glutathione Reductase, His-tagged

Cat. No.: GSR-1318H
Product Overview: Recombinant human GSR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: GSR is a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein and plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ->2GSH + NADP+. In most eukaryotic cells, GSR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol, 0.1 M NaCl.
Molecular Weight: 54.3 kDa (504 aa) confirmed by MALDI-TOF
Purity: > 95 % by SDS-PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSMAMACRQ EPQPQGPPPA AGAVASYDYL VIGGGSGGLA SARRAAELGA RAAVVESHKL GGTCVNVGCV PKKVMWNTAV HSEFMHDHAD YGFPSCEGKF NWRVIKEKRD AYVSRLNAIY QNNLTKSHIE IIRGHAAFTS DPKPTIEVSG KKYTAPHILI ATGGMPSTPH ESQIPGASLG ITSDGFFQLE ELPGRSVIVG AGYIAVEMAG ILSALGSKTS LMIRHDKVLR SFDSMISTNC TEELENAGVE VLKFSQVKEV KKTLSGLEVS MVTAVPGRLP VMTMIPDVDC LLWAIGRVPN TKDLSLNKLG IQTDDKGHII VDEFQNTNVK GIYAVGDVCG KALLTPVAIA AGRKLAHRLF EYKEDSKLDY NNIPTVVFSH PPIGTVGLTE DEAIHKYGIE NVKTYSTSFT PMYHAVTKRK TKCVMKMVCA NKEEKVVGIH MQGLGCDEML QGFAVAVKMG ATKADFDNTV AIHPTSSEEL VTLR
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Glutathione metabolism; Metabolism of nucleotides; Oxidative Stress; Selenium Pathway; Synthesis and interconversion of nucleotide di- and triphosphates; ascorbate glutathione cycle; glutathione redox reactions I;glutathione redox reactions II
Gene Name: GSR glutathione reductase [ Homo sapiens ]
Official Symbol: GSR
Synonyms: GSR; glutathione reductase; MGC78522; glutathione reductase, mitochondrial; GR; GRase; OTTHUMP00000225449; OTTHUMP00000225451; NP_000628.2; EC 1.8.1.7
Gene ID: 2936
mRNA Refseq: NM_000637
Protein Refseq: NP_000628
MIM: 138300
UniProt ID: P00390
Chromosome Location: 8p21.1
Function: NADP binding; electron carrier activity; flavin adenine dinucleotide binding; glutathione binding; glutathione-disulfide reductase activity; oxidoreductase activity; protein homodimerization activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.