"PSMA5" Related Products

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Recombinant Human Proteasome (prosome, macropain) Subunit, Alpha Type, 5, His-tagged

Cat. No.: PSMA5-1336H
Product Overview: Recombinant human PSMA5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: PSMA5 (Proteasome subunit alpha type-5) belongs to the peptidase T1A family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMA5 has been shown to interact with PLK1. This peptidase has a very broad specificity for cleavage of peptide bonds.
Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT, 10% glycerol, 100 mM NaCl.
Molecular Weight: 30.5 kDa (277 aa), confirmed by MALDI-TOF
Purity: > 95 % by SDS-PAGE
Concentration: 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMFLT RSEYDRGVNT FSPEGRLFQV EYAIEAIKLG STAIGIQTSE GVCLAVEKRI TSPLMEPSSI EKIVEIDAHI GCAMSGLIAD AKTLIDKARV ETQNHWFTYN ETMTVESVTQ AVSNLALQFG EEDADPGAMS RPFGVALLFG GVDEKGPQLF HMDPSGTFVQ CDARAIGSAS EGAQSSLQEV YHKSMTLKEA IKSSLIILKQ VMEEKLNATN IELATVQPGQ NFHMFTKEEL EEVIKDI
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: APC/C-mediated degradation of cell cycle proteins; Adaptive Immunity Signaling; Apoptosis; Assembly of the pre-replicative complex; Cell Cycle Checkpoints; DNA Replication; DNA Replication Pre-Initiation; G1/S DNA Damage Checkpoints; HIV Infection; Immune System; Immunoproteasome; M/G1 Transition; Metabolism of RNA; Synthesis of DNA
Gene Name: PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 [ Homo sapiens ]
Official Symbol: PSMA5
Synonyms: PSMA5; proteasome (prosome, macropain) subunit, alpha type, 5; PSC5; ZETA; FLJ42315; MGC117302; MGC125802; MGC125803; MGC125804; proteasome subunit alpha type-5; OTTHUMP00000013792; macropain zeta chain; proteasome zeta chain; macropain subunit zeta; proteasome component 5; proteasome subunit zeta; proteasome alpha 5 subunit; multicatalytic endopeptidase complex zeta chain; NP_001186701.1; EC 3.4.25.1
Gene ID: 5686
mRNA Refseq: NM_001199772
Protein Refseq: NP_001186701
MIM: 176844
UniProt ID: P28066
Chromosome Location: 1p13
Function: peptidase activity; protein binding; threonine-type endopeptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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