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Recombinant Human Dehydrogenase/Reductase (SDR Family) Member 9, His-tagged

Cat.No. : DHRS9-1561H
Product Overview : Recombinant human DHRS9 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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  • Gene Information
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Cat. No. : DHRS9-1561H
Description : DHRS9, also known as dehydrogenase/reductase SDR family member 9, functions as a homotetramer that converts both 3-alpha-tetrahydroprogesterone (allopregnanolone) and 3-alpha-androstanediol to dihydroxyprogesterone and is thought to play a role in retinoic acid biosynthesis.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 2mM DTT, 0.1mM PMSF.
Molecular Weight : 35.9 kDa (327aa), confirmed by MALDI-TOF.
Purity : >90% by SDS-PAGE
Concentration : 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGSHMRKGKL KIEDITDKYI FITGCDSGFG NLAARTFDKK GFHVIAACLT ESGSTALKAE TSERLRTVLLDVTDPENVKR TAQWVKNQVG EKGLWGLINN AGVPGVLAPT DWLTLEDYRE PIEVNLFGLI SVTLNMLPLV KKAQGRVINV SSVGGRLAIVGGGYTPSKYA VEGFNDSLRR DMKAFGVHVS CIEPGLFKTN LADPVKVIEK KLAIWEQLSP DIKQQYGEGY IEKSLDKLKG NKSYVNMDLSPVVECMDHAL TSLFPKTHYA AGKDAKIFWI PLSHMPAALQ DFLLLKQKAE LANPKAV
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Metabolic pathways; Retinol metabolism
Gene Name : DHRS9 dehydrogenase/reductase (SDR family) member 9 [ Homo sapiens ]
Official Symbol : DHRS9
Synonyms : DHRS9; dehydrogenase/reductase (SDR family) member 9; RDHL; RDH15; RDHTBE; SDR9C4; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD; OTTHUMP00000163043; OTTHUMP00000204923; OTTHUMP00000204925; OTTHUMP00000204926; OTTHUMP00000205057; retinol dehydrogenase homolog; 3-alpha hydroxysteroid dehydrogenase; short-chain dehydrogenase/reductase retSDR8; NADP-dependent retinol dehydrogenase/reductase; short chain dehydrogenase/reductase family 9C, member 4; 3alpha-HSD; dehydrogenase/reductase SDR family member 9; EC 1.1; RDH-E2; EC 1.1.1; EC 1.1.1.105
Gene ID : 10170
mRNA Refseq : NM_001142270
Protein Refseq : NP_001135742
MIM : 612131
UniProt ID : Q9BPW9
Chromosome Location : 2q31.1
Function : alcohol dehydrogenase (NAD) activity; binding NAS PubMed; retinol dehydrogenase activity; testosterone dehydrogenase (NAD+) activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can lifestyle changes reduce the risk for DHRS9 mutations? 11/19/2022

There is currently no definitive way to alter the variation of the DHRS9 gene. However, healthy lifestyles, such as a balanced diet, moderate exercise, and good social interactions, may help reduce the risk of neurological disorders, although they may not directly improve the effects of the DHRS9 gene variant.

What is the effect of mutations in the DHRS9 gene? 11/16/2022

Mutations in the DHRS9 gene may cause abnormal function of retinoic acid-binding protein 1, which in turn affects retinoic acid metabolism and may increase the risk of neurological diseases.

Are DHRS9 gene variants associated with cognitive function 08/31/2022

Studies have shown that mutations in the DHRS9 gene may affect cognitive function, but the specific mechanism still needs further research.

What might be involved in future studies of the DHRS9 gene? 08/05/2022

Future research on the DHRS9 gene may involve more in-depth studies of molecular mechanisms, disease associations, and the development of therapeutics for this gene variant.

Are variants in the DHRS9 gene associated with behavioral traits? 07/04/2022

Studies have shown that mutations in the DHRS9 gene may be associated with certain behavioral traits, such as social skills, attention, and impulse control.

How to detect variants in the DHRS9 gene? 04/16/2020

Variants in the DHRS9 gene, including single nucleotide polymorphisms (SNPs), insertions/deletions, etc., can be detected by gene sequencing technology.

Customer Reviews (3)

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Reviews
10/24/2022

    DHRS9 is highly specific and active, and does not cause abnormal immune responses.

    04/22/2022

      The product is very mature and can be used for scientific research.

      10/19/2020

        The solubility is very good and can be easily dissolved in a variety of buffers.

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