Recombinant Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase, His-tagged
Cat.No. : | HMGCL-1562H |
Product Overview : | Recombinant human HMGCL protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | HMGCL-1562H |
Description : | HMGCL, also known as hydroxymethylglutaryl-CoA lyase, is a mitochondrial matrix protein that belongs to the HMG-CoA lyase family. It exists as a homodimer and participates in leucine catabolism and ketogenesis, the hepatic synthesis of ketone bodies that, during fasting, provide a major source of energy for heart, brain and kidney. More specifically, it catalyzes the final step of these processes, the cleavage of 3-hydroxy-3-methylglutaryl-CoA to acetoacetic acid and acetyl-CoA. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea. |
Molecular Weight : | 34.2 kDa (323aa) |
Purity : | >85% by SDS-PAGE |
Concentration : | 1.0 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGSHMTLPKR VKIVEVGPRD GLQNEKNIVS TPVKIKLIDM LSEAGLSVIE TTSFVSPKWV PQMGDHTEVLKGIQKFPGIN YPVLTPNLKG FEAAVAAGAK EVVIFGAASE LFTKKNINCS IEESFQRFDA ILKAAQSANI SVRGYVSCAL GCPYEGKISPAKVAEVTKKF YSMGCYEISL GDTIGVGTPG IMKDMLSAVM QEVPLAALAV HCHDTYGQAL ANTLMALQMG VSVVDSSVAG LGGCPYAQGASGNLATEDLV YMLEGLGIHT GVNLQKLLEA GNFICQALNR KTSSKVAQAT CKL |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Butanoate metabolism; Fatty acid; Formation of Acetoacetic Acid; Ketone body metabolism; Metabolic pathways; Metabolism of lipids and lipoproteins; Peroxisome; Synthesis and Degradation of Ketone Bodies; Synthesis of Ketone Bodies; Valine |
Gene Name : | HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase [ Homo sapiens ] |
Official Symbol : | HMGCL |
Synonyms : | HMGCL; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; HL; hydroxymethylglutaryl-CoA lyase, mitochondrial; HMG-CoA lyase; OTTHUMP00000003005; OTTHUMP00000223529; OTTHUMP00000223530; EC 4.1.3.4; hydroxymethylglutaricaciduria; 3-hydroxy-3-methylglutaryl-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase |
Gene ID : | 3155 |
mRNA Refseq : | NM_000191 |
Protein Refseq : | NP_000182 |
MIM : | 613898 |
UniProt ID : | P35914 |
Chromosome Location : | 1p36.1-p35 |
Function : | carboxylic acid binding; fatty-acyl-CoA binding; hydroxymethylglutaryl-CoA lyase activity; lyase activity; metal ion binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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