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Recombinant Human Proteasome (prosome, macropain) Subunit, Alpha Type, 4, His-tagged

Cat.No. : PSMA4-1565H
Product Overview : Recombinant human PSMA4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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Cat. No. : PSMA4-1565H
Description : PSMA4, also known as proteasome subunit alpha type 4, is a member of the peptidase T1A family that is a 20S core alpha subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. It is distributed throughout eukaryotic cells at a high concentration and cleaves peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
Form : Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 1mM DTT, 0.1mM PMSF.
Molecular Weight : 32.0 kDa (285aa), confirmed by MALDI-TOF.
Purity : >95% by SDS-PAGE
Concentration : 1 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGSHMSRRYD SRTTIFSPEG RLYQVEYAME AIGHAGTCLG ILANDGVLLA AERRNIHKLL DEVFFSEKIYKLNEDMACSV AGITSDANVL TNELRLIAQR YLLQYQEPIP CEQLVTALCD IKQAYTQFGG KRPFGVSLLY IGWDKHYGFQ LYQSDPSGNYGGWKATCIGN NSAAAVSMLK QDYKEGEMTL KSALALAIKV LNKTMDVSKL SAEKVEIATL TRENGKTVIR VLKQKEVEQL IKKHEEEEAKAEREKKEKEQ KEKDK
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdc20 mediated degradation of mitotic proteins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins; Adaptive Immunity Signaling; Antigen processing: Ubiquitination& Proteasome degradation; Apoptosis; Assembly of the pre-replicative complex; Autodegradation of Cdh1 by Cdh1:APC/C; Autodegradation of the E3 ubiquitin ligase COP1; CDK-mediated phosphorylation and removal of Cdc6; CDT1 association with the CDC6:ORC:origin complex; Cell Cycle Checkpoints; Cell Cycle
Gene Name : PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 [ Homo sapiens ]
Official Symbol : PSMA4
Synonyms : PSMA4; proteasome (prosome, macropain) subunit, alpha type, 4; HC9; PSC9; HsT17706; MGC12467; MGC24813; MGC111191; proteasome subunit alpha type-4; OTTHUMP00000185020; macropain subunit C9; proteasome subunit L; proteasome subunit HC9; proteasome component C9; multicatalyticendopeptidase complex subunit C9; EC 3.4.25.1; Macropain subunit C9; Multicatalyticendopeptidase complex subunit C9; Proteasome component C9
Gene ID : 5685
mRNA Refseq : NM_001102667
Protein Refseq : NP_001096137
MIM : 176846
UniProt ID : P25789
Chromosome Location : 15q25.1
Function : peptidase activity; protein binding; threonine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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