"PTPMT1" Related Products

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Recombinant Human Protein Tyrosine Phosphatase, Mitochondrial 1, His-tagged

Cat. No.: PTPMT1-1568H
Product Overview: Recombinant human PTPMT1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: PTPMT1 (protein tyrosine phosphatase mitochondrial 1), also known as MOSP or PLIP (phosphoinositide lipid phosphatase) and previouslyknown as DUSP23, is a widely expressed PTP membrane protein with high expression levels in pancreatic beta cells. This protein exclusively localizes to the matrix face of the inner membrane of the mitochondrion. It is responsible for dephosphorylating mitochondrial proteins and therefore plays a significant role in the production of ATP and secretion of insulin. For its substrate, PTPMT1 displays a specific preference for the lipid signaling molecule phosphatidylinositol 5-phosphate.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.15mM NaCl.
Molecular Weight: 22.6 kDa (199aa), confirmed by MALDI-TOF.
Purity: >95% by SDS-PAGE
Concentration: 1 mg/ml (determined by Bradford)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMKVPGR AHRDWYHRID PTVLLGALPL RSLTRQLVQD ENVRGVITMN EEYETRFLCN SSQEWKRLGV EQLRLSTVDM TGIPTLDNLQ KGVQFALKYQ SLGQCVYVHC KAGRSRSATM VAAYLIQVHK WSPEEAVRAI AKIRSYIHIR PGQLDVLKEF HKQITARATK DGTFVISKT
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: 3-phosphoinositide degradation
Gene Name: PTPMT1 protein tyrosine phosphatase, mitochondrial 1 [ Homo sapiens ]
Official Symbol: PTPMT1
Synonyms: PTPMT1; protein tyrosine phosphatase, mitochondrial 1; MOSP; PLIP; DUSP23; FLJ46081; PNAS-129; protein-tyrosine phosphatase mitochondrial 1; OTTHUMP00000234343; OTTHUMP00000234346; OTTHUMP00000234347; PTEN-like phosphatase; phosphoinositide lipid phosphatase; NB4 apoptosis/differentiation related protein; protein-tyrosine phosphatase mitochondrial 1; EC 3.1.3.16; Phosphoinositide lipid phosphatase; EC 3.1.3.48
Gene ID: 114971
mRNA Refseq: NM_001143984
Protein Refseq: NP_001137456
MIM: 609538
UniProt ID: Q8WUK0
Chromosome Location: 11p11.2
Function: hydrolase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein tyrosine phosphatase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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