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Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)

Cat.No. : SNCA-5126H
Product Overview : Recombinant human SNCA was expressed in E. coli and purified by using conventional chromatography techniques.
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Cat. No. : SNCA-5126H
Description : A Parkinsons disease-related point mutant (A53T) of alpha-synuclein. A53T mutant of alpha-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid In 20mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl.
Purity : > 95% by SDS - PAGE
Sequence : MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Molecular Mass : 14.4 kDa (140 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ]
Official Symbol : SNCA
Synonyms : SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP)
Gene ID : 6622
mRNA Refseq : NM_000345
Protein Refseq : NP_000336
MIM : 163890
UniProt ID : P37840
Chromosome Location : 4q21
Pathway : Alzheimer"s disease; Neurodegenerative Disorders; Parkinson"s disease
Function : zinc ion binding; tau protein binding; protein binding; phosphoprotein binding; NOT phospholipase D inhibitor activity; NOT fatty acid binding; magnesium ion binding; kinesin binding; identical protein binding; Hsp70 protein binding; histone binding; ferrous iron binding; dynein binding; caspase inhibitor activity; calcium ion binding; arachidonic acid binding; alpha-tubulin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can SNCA protein levels in cerebrospinal fluid be used as a diagnostic marker for Parkinson's disease? 10/11/2022

Yes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.

What potential therapeutic strategies target SNCA protein for Parkinson's disease treatment? 03/27/2022

Therapies may include reducing SNCA aggregation or preventing its misfolding.

Are there any genetic mutations related to SNCA protein that increase the risk of Parkinson's disease? 10/17/2018

Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.

How is SNCA protein associated with neurodegenerative diseases? 06/11/2016

Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.

Are there any ongoing clinical trials investigating SNCA-related therapies? 05/27/2016

Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.

Customer Reviews (3)

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Reviews
08/31/2020

    Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

    03/12/2020

      Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.

      10/16/2017

        In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

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