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Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b, His-tagged

Cat.No. : TNFRSF11B-5142H
Product Overview : Recombinant human osteoprotegerin protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques
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Cat. No. : TNFRSF11B-5142H
Description : Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF)-related family, is referred to as TNFRSF11B and part of the OPG/receptor activator of NF-kB ligand (RANKL)/receptor activator of NF-kB (RANK) triad. This cytokine that lacks any apparent cell-association motifs and exists as a soluble secreted protein, network regulates the differentiation and activation of osteoclasts and hence the critical balance between bone formation (osteoblasts) and bone resorption (osteoclasts).
Concentration : 0.5 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in PBS, pH 7.4, containing 10% glycerol.
Purity : > 85 % by SDS - PAGE
Sequence : 22-401 amino acids: ADPETFPPKY LHYDEETSHQ LLCDKCPPGT YLKQHCTAKW KTVCAPCPDH YYTDSWHTSD ECLYCSPVCK ELQYVKQECN RTHNRVCECK EGRYLEIEFC LKHRSCPPGF GVVQAGTPER NTVCKRCPDG FFSNETSSKA PCRKHTNCSV FGLLLTQKGN ATHDNICSGN SESTQKCGID VTLCEEAFFR FAVPTKFTPN WLSVLVDNLP GTK
Molecular Mass : 45.6 kDa (398 aa) (On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated rhOPG protein will be appeared at approximately 55 kDa)
Applications : SDS-PAGE
Endotoxin Levels : < 1.0 EU per ug of protein (determined by LAL method)
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [ Homo sapiens ]
Official Symbol : TNFRSF11B
Synonyms : TNFRSF11B; OPG; OCIF; Osteoclastogenesis inhibitory factor; TR1; MGC29565; Osteoprotegerin; Osteoclastogenesis inhibitory factor; tumor necrosis factor receptor superfamily, member 11b
Gene ID : 4982
mRNA Refseq : NM_002546
Protein Refseq : NP_002537
MIM : 602643
UniProt ID : O00300
Chromosome Location : 8q24
Pathway : Cytokine-cytokine receptor interaction; Monoamine Transport; Osteoblast Signaling; Osteoclast differentiation
Function : Binding; cytokine activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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