Active Recombinant Human ERBB3 Protein
Cat.No. : | ERBB3-23H |
Product Overview : | Recombinant human ERBB3 protein produced in E.coli is a single, non-glycosylated polypeptide consisting of several epitopes of extracellular domain of human Erb-b3. |
- Specification
- Gene Information
- Related Products
Source : | E.coli |
Species : | Human |
Bio-activity : | Measured by its ability to postpone tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibit the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice. |
Molecular Mass : | 12.0 kDa |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Stability : | ErbB3 although stable at 4 centigrade for 1 week, should be stored below -18 centigrade. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Concentration : | 1 mg/mL |
Storage Buffer : | Each mg protein contains 1 mg aluminum hydroxide 10 mM arginine, 10 mM sodium chloride, 20 mM sodium phosphate buffer and 5 mM potassium phosphate. |
Dilutions : | It is recommended that sterile phosphate-buffered saline containing 1 mg aluminum hydroxide be added to the vial to prepare a stock solution. |
Shipping : | Shipped with ice packs. |
Gene Name : | ERBB3 erb-b2 receptor tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | ERBB3 |
Synonyms : | ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; human epidermal growth factor receptor 3; proto-oncogene-like protein |
Gene ID : | 2065 |
mRNA Refseq : | NM_001982 |
Protein Refseq : | NP_001973 |
MIM : | 190151 |
UniProt ID : | P21860 |
Products Types
◆ Recombinant Protein | ||
ERBB3-02HM | Recombinant Human ERBB3 Protein (E928G), His tagged | +Inquiry |
ERBB3-28H | Active Recombinant Human ERBB3 Protein (Ser20-Gly538), C-6×His tagged | +Inquiry |
ERBB3-858H | Recombinant Human ERBB3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Erbb3-43M | Recombinant Mouse Erbb3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERBB3-235H | Recombinant Human ERBB3 Protein, His-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1765MCL | Recombinant Mouse ERBB3 cell lysate | +Inquiry |
ERBB3-1721RCL | Recombinant Rhesus ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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