Recombinant Human Growth Differentiation Factor 15, His-tagged

• Cat.No.: GDF15-626H
• Product Overview: GDF-15, fused to His-tag, was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Specification

• Cat. No.: GDF15-626H
• Description: Growth differentiation factor 15 (GDF-15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.
• Concentration: 0.5 mg/ml
• Source: Human
• Host: E. coli
• Form: Supplied as a liquid in 10mM sodium citrate, pH 3.5, containing 10% glycerol.
• Purity: > 95% by SDS - PAGE
• Sequence: 195-308 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I
• Molecular Mass: 16.7 kDa (151aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
• Applications: SDS - PAGE
• Endotoxin Levels: < 1.0 EU per ug of protein (determined by LAL method )
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: GDF15 growth differentiation factor 15 [ Homo sapiens ]
• Official Symbol: GDF15
• Synonyms: GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein; Growth/differentiation factor 15
• Gene ID: 9518
• mRNA Refseq: NM_004864
• Protein Refseq: NP_004855
• MIM: 605312
• UniProt ID: Q99988
• Chromosome Location: 19p13.11
• Pathway: Direct p53 effectors
• Function: cytokine activity; growth factor activity