"CUL1" Related Products

Expand

Recombinant Human Cullin 1, His-tagged

Cat. No.: CUL1-4989H
Product Overview: Recombinant human CUL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Description: Cullin1, also known as CUL1, is a core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cullin1 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
Concentration: 1 mg/ml
Source: Human
Host: E. coli
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 10% glycerol and 100mM NaCl.
Purity: > 95% by SDS - PAGE
Sequence: 1-410 amino acids: MGSSHHHHHH SSGLVPRGSH MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT NAVLKLIEKE RNGE
Molecular Mass: 49.4 kDa (430aa) confirmed by MALDI-TOF
Applications: SDS-PAGE
Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: CUL1 cullin 1 [ Homo sapiens ]
Official Symbol: CUL1
Synonyms: CUL1; cullin 1; MGC149834; MGC149835; cullin-1; CUL-1; OTTHUMP00000202347
Gene ID: 8454
mRNA Refseq: NM_003592
Protein Refseq: NP_003583
MIM: 603134
UniProt ID: Q13616
Chromosome Location: 7q36.1
Pathway: APC/C-mediated degradation of cell cycle proteins; Canonical Wnt signaling pathway; Cell Cycle; Circadian Clock; Circadian rhythm – mammal; Cyclin E associated events during G1/S transition; Degradation of beta-catenin by the destruction complex; Delta-Notch Signaling Pathway; G1/S Transition; Interleukin-1 signaling; Mitotic G1-G1/S phases; Notch signaling pathway; Oocyte meiosis; Protein processing in endoplasmic reticulum; Regulation of APC/C activators between G1/S and early anaphase
Function: protein binding; ubiquitin protein ligase binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.