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Recombinant Human Defensin, Beta 4A

Cat. No. : DEFB4A-037H
Product Overview : Recombinant human protein was expressed in E.coli and purified by using conventional chromatography techniques.
Description : Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
Source : Human
Host : E.coli
Form : Supplied lyophilized with no additives. Reconstitute in 10 mM Acetic Acid to a concentration of 0.1 - 1.0 mg/ml.
Purity : >98% pure by SDS PAGE and HPLC
Sequence : Region of BD2 protein corresponding to amino acids GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P.
Molecular Mass : 4.3 kDa
Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels : Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity : Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml.
Storage : Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : DEFB4A defensin, beta 4A [ Homo sapiens ]
Official Symbol : DEFB4A
Synonyms : DEFB4A; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102; BD-2; DEFB4B; hBD-2; defensin, beta 4A; beta-defensin 4A; defensin, beta 2; defensin, beta 4; OTTHUMP00000159651; skin-antimicrobial peptide 1; Beta-defensin 2
Gene ID : 1673
mRNA Refseq : NM_004942
Protein Refseq : NP_004933
MIM : 602215
UniProt ID : O15263
Chromosome Location : 8p23.1

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