"FGF23" Related Products

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Recombinant Human Fibroblast Growth Factor 23

Cat. No.: FGF23-618H
Product Overview: Recombinant human FGF23 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Description: The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF23, FGF21 and FGF19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.
Source: Human
Host: E.coli
Form: Supplied as a lyophilized powder.
Purity: > 95% by SDS - PAGE
Sequence: Region of FGF23 protein corresponding to amino acids MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCS
Molecular Mass: 22.5 kDa
Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: FGF23 fibroblast growth factor 23 [ Homo sapiens ]
Official Symbol: FGF23
Synonyms: FGF23; fibroblast growth factor 23; ADHR; HYPF; HPDR2; PHPTC; FGF-23; Phosphatonin; UNQ3027/PRO9828; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor
Gene ID: 8074
mRNA Refseq: NM_020638
Protein Refseq: NP_065689
MIM: 605380
UniProt ID: Q9GZV9
Chromosome Location: 12p13.3
Pathway: MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR
Function: growth factor activity

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